Effect of valsartan addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients

R. Fogari, A. Zoppi, G. Derosa, A. Mugellini, P. Lazzari, A. Rinaldi, E. Fogari, P. Preti

Research output: Contribution to journalArticle

Abstract

The aim of this study was to assess the effect of valsartan addition to amlodipine on ankle foot volume (AFV) and pretibial subcutaneous tissue pressure (PSTP), two objective measures of ankle oedema. After a 4-week placebo period, 80 grade 1-2 hypertensive patients (diastolic blood pressure (DBP)>90mmHg and 140mmHg) were randomized to amlodipine 10mg or valsartan 160mg or amlodipine 10mg plus valsartan 160mg for 6 weeks according to an open-label, blinded end point, crossover design. At the end of the placebo period and of each treatment period, blood pressure, AFV and PSTP were evaluated. AFV was measured using the principle of water displacement. PSTP was assessed connecting the subcutaneous pretibial interstitial environment with a water manometer. Both amlodipine and valsartan monotherapy significantly reduced SBP (-16.9 and -14.5mmHg, respectively, P

Original languageEnglish
Pages (from-to)220-224
Number of pages5
JournalJournal of Human Hypertension
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 2007

ASJC Scopus subject areas

  • Internal Medicine

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