TY - JOUR
T1 - Effect of valsartan addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients
AU - Fogari, R.
AU - Zoppi, A.
AU - Derosa, G.
AU - Mugellini, A.
AU - Lazzari, P.
AU - Rinaldi, A.
AU - Fogari, E.
AU - Preti, P.
PY - 2007/3
Y1 - 2007/3
N2 - The aim of this study was to assess the effect of valsartan addition to amlodipine on ankle foot volume (AFV) and pretibial subcutaneous tissue pressure (PSTP), two objective measures of ankle oedema. After a 4-week placebo period, 80 grade 1-2 hypertensive patients (diastolic blood pressure (DBP)>90mmHg and 140mmHg) were randomized to amlodipine 10mg or valsartan 160mg or amlodipine 10mg plus valsartan 160mg for 6 weeks according to an open-label, blinded end point, crossover design. At the end of the placebo period and of each treatment period, blood pressure, AFV and PSTP were evaluated. AFV was measured using the principle of water displacement. PSTP was assessed connecting the subcutaneous pretibial interstitial environment with a water manometer. Both amlodipine and valsartan monotherapy significantly reduced SBP (-16.9 and -14.5mmHg, respectively, P
AB - The aim of this study was to assess the effect of valsartan addition to amlodipine on ankle foot volume (AFV) and pretibial subcutaneous tissue pressure (PSTP), two objective measures of ankle oedema. After a 4-week placebo period, 80 grade 1-2 hypertensive patients (diastolic blood pressure (DBP)>90mmHg and 140mmHg) were randomized to amlodipine 10mg or valsartan 160mg or amlodipine 10mg plus valsartan 160mg for 6 weeks according to an open-label, blinded end point, crossover design. At the end of the placebo period and of each treatment period, blood pressure, AFV and PSTP were evaluated. AFV was measured using the principle of water displacement. PSTP was assessed connecting the subcutaneous pretibial interstitial environment with a water manometer. Both amlodipine and valsartan monotherapy significantly reduced SBP (-16.9 and -14.5mmHg, respectively, P
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U2 - 10.1038/sj.jhh.1002140
DO - 10.1038/sj.jhh.1002140
M3 - Article
C2 - 17215848
AN - SCOPUS:33847044811
VL - 21
SP - 220
EP - 224
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
SN - 0950-9240
IS - 3
ER -