Effect of valsartan or olmesartan addition to amlodipine on ankle edema in hypertensive patients

Roberto Fogari, Gian Malamani, Luca Corradi, Amedeo Mugellini, Paola Preti, Annalisa Zoppi, Giuseppe Derosa

Research output: Contribution to journalArticle

Abstract

Introduction: The objective of this study was to compare the effect on ankle edema of adding valsartan (V) or olmesartan (O) to amlodipine (A) in the treatment of hypertension. Methods: After a 4-week placebo period, 74 adult outpatients with essential hypertension (diastolic blood pressure [DBP] >90 and 140 mmHg) were treated with A 10 mg once daily for 4 weeks. Thereafter, nonresponder patients (DBP >90 mmHg and/or SBP >140 mmHg; n=51) were randomized to receive additional V 160 mg once daily or O 20 mg once daily for 8 weeks in two crossover periods, each separated by a 4-week placebo period. Clinic blood pressure (BP), heart rate, and ankle/foot volume (AFV) were evaluated and blood samples were drawn to evaluate plasma norepinephrine (NE) levels. Results: Both V/A and O/A induced a greater SBP/DBP reduction than A monotherapy (-26.4/-20.8 mmHg and -24.4/-19.1 mmHg, respectively; all P

Original languageEnglish
Pages (from-to)48-55
Number of pages8
JournalAdvances in Therapy
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Amlodipine
  • Ankle edema
  • Combination therapy
  • Hypertens ion
  • Olmesartan
  • Valsartan

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine(all)

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