Effect of Verapamil on aldosterone secretion in primary aldosteronism

G. Opocher, S. Rocco, A. Murgia, F. Mantero

Research output: Contribution to journalArticle

Abstract

Intracytoplasmic calcium seems to act as second messenger for aldosterone secretion. Both in vitro and in vivo studies demonstrate that drugs which block calcium entry cause a decreased responsiveness of glomerulosa cells to Angiotensin II and potassium. In order to evaluate the effect of a calcium channel blocking agent (Verapamil) in conditions of abnormal aldosterone secretion, we have studied 11 patients with primary aldosteronism, 5 with idiopathic hyperaldosteronism (IHA) and 6 with aldosterone producing adenoma (APA). In our study plasma aldosterone levels decreased after Verapamil infusion in IHA whereas no significant variations were observed in APA patients. These results suggest that calcium blockade can interfere with a possible regulatory system which plays a greater role in idiopathic aldosteronism.

Original languageEnglish
Pages (from-to)491-494
Number of pages4
JournalJournal of Endocrinological Investigation
Volume10
Issue number5
DOIs
Publication statusPublished - 1987

Keywords

  • Aldosterone
  • calcium
  • hypertension
  • primary aldosteronism
  • renin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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