Effect of verapamil on the aldosterone-stimulating properties of metoclopramide: In vitro and in vivo studies

G. Opocher, A. Murgia, S. Rocco, D. D'Agostino, M. Boscaro, A. Menegus, F. Mantero

Research output: Contribution to journalArticle

Abstract

The role of calcium in the regulation of aldosterone secretion has been recently clarified. Angiotensin II and potassium stimulate aldosterone secretion through a calcium-entry dependent mechanism, while ACTH action is both calcium and cyclic AMP dependent. To establish whether also the so-called aldosterone dopaminergic regulatory system is calcium-dependent we have studied, in vitro and in vivo, the effect of verapamil, a calcium entry blocker agent, on the aldosterone-stimulating properties of the antidopaminergic drug, metoclopramide. In the rat adrenal cells perfusion system, verapamil blocked both angiotensin II and metoclopramide-stimulated aldosterone. This effect on metoclopramide action seems to be present also in vivo in normal subjects: in fact aldosterone response was slightly but significantly reduced after pretreatment with verapamil. In conclusion the results suggest that also the dopaminergic system could regulate aldosterone secretion through calcium-mediated mechanisms.

Original languageEnglish
Pages (from-to)775-778
Number of pages4
JournalHormone and Metabolic Research
Volume18
Issue number11
Publication statusPublished - 1986

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Opocher, G., Murgia, A., Rocco, S., D'Agostino, D., Boscaro, M., Menegus, A., & Mantero, F. (1986). Effect of verapamil on the aldosterone-stimulating properties of metoclopramide: In vitro and in vivo studies. Hormone and Metabolic Research, 18(11), 775-778.