Effect of verapamil versus nicardipine on 24-hour blood pressure

G. Tonolo, P. Pinna Parpaglia, C. Troffa, M. G. Melis, G. Sabino, A. Pazzola, G. Patteri, F. Pala, P. Madeddu, N. Glorioso

Research output: Contribution to journalArticle

Abstract

Thirty patients with uncomplicated, mild to moderate essential hypertension entered a comparative open study of the efficacy and tolerability of slow-release verapamil versus nicardipine. After a 2-week washout period, patients were randomly allocated to receive either verapamil SR 240 mg once daily or nicardipine 40 mg BID for 6 weeks. Lisinopril 10 mg once daily was added after 3 weeks of treatment if the sitting diastolic blood pressure was >95 mmHg. Twenty-four-hour blood pressure monitoring was performed at week 0 and after 3 and 6 weeks of treatment. Within the first 2 weeks, four patients in the nicardipine group withdrew from the study because of tachycardia (n = 2) or headache (n = 2). Three patients in both groups needed the addition of lisinopril. A significant and comparable reduction in systolic and diastolic blood pressures over 24 hours was obtained after 3 and 6 weeks with both treatments (P <0.01). We conclude that verapamil SR 240 mg once daily is an effective and well-tolerated antihypertensive drug that does not interfere with the circadian rhythm of blood pressure. Its once-a-day formulation may increase patient compliance with the antihypertensive treatment.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCurrent Therapeutic Research
Volume53
Issue number1
DOIs
Publication statusPublished - 1993

Fingerprint

Nicardipine
Verapamil
Blood Pressure
Lisinopril
Antihypertensive Agents
Therapeutics
Patient Compliance
Circadian Rhythm
Tachycardia
Headache

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tonolo, G., Parpaglia, P. P., Troffa, C., Melis, M. G., Sabino, G., Pazzola, A., ... Glorioso, N. (1993). Effect of verapamil versus nicardipine on 24-hour blood pressure. Current Therapeutic Research, 53(1), 1-8. https://doi.org/10.1016/S0011-393X(05)80148-1

Effect of verapamil versus nicardipine on 24-hour blood pressure. / Tonolo, G.; Parpaglia, P. Pinna; Troffa, C.; Melis, M. G.; Sabino, G.; Pazzola, A.; Patteri, G.; Pala, F.; Madeddu, P.; Glorioso, N.

In: Current Therapeutic Research, Vol. 53, No. 1, 1993, p. 1-8.

Research output: Contribution to journalArticle

Tonolo, G, Parpaglia, PP, Troffa, C, Melis, MG, Sabino, G, Pazzola, A, Patteri, G, Pala, F, Madeddu, P & Glorioso, N 1993, 'Effect of verapamil versus nicardipine on 24-hour blood pressure', Current Therapeutic Research, vol. 53, no. 1, pp. 1-8. https://doi.org/10.1016/S0011-393X(05)80148-1
Tonolo, G. ; Parpaglia, P. Pinna ; Troffa, C. ; Melis, M. G. ; Sabino, G. ; Pazzola, A. ; Patteri, G. ; Pala, F. ; Madeddu, P. ; Glorioso, N. / Effect of verapamil versus nicardipine on 24-hour blood pressure. In: Current Therapeutic Research. 1993 ; Vol. 53, No. 1. pp. 1-8.
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