Effect of vigabatrin (gamma-vinyl-GABA) on visual, brainstem auditory and somatosensory evoked potentials in epileptic patients

V. Cosi, R. Callieco, C. A. Galimberti, R. Manni, A. Tartara, G. Lanzi, U. Balottin, E. Perucca

Research output: Contribution to journalArticle

Abstract

Visual (V), somatosensory (S) and brainstem auditory (BA) evoked potentials (EPs) were determined in 22 epileptic patients, mostly with partial seizures, who received add-on treatment with vigabatrin (1-3 g/day, stratified according to body weight) and placebo, each given for 7 weeks according to a double-blind, randomized cross-over design. At pretreatment assessment, BAEPs and SEPs were found to be within normal limits in most of the patients tested, while for VEPs several abnormal responses were found, including a marked prolongation of PI00 latency values in the majority of cases. None of the EP parameters examined was significantly influenced by vigabatrin treatment. These results support the evidence that enhancement of GABA-ergic transmission does not substantially affect the functional state of afferent sensory pathways as assessed by EP analysis. The significance of these findings with respect to the safety of vigabatrin therapy is discussed.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalEuropean Neurology
Volume28
Issue number1
DOIs
Publication statusPublished - 1988

Keywords

  • Epilepsy
  • Evoked potentials
  • Gamma-vinyl-GABA
  • Vigabatrin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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