EFFETTO DELLA VILOXAZINA SULLA FARMACOCINETICA DELL'EPOSSIDO DELLA CARBAMAZEPINA

Translated title of the contribution: Effect of viloxazine on the pharmacokinetics of carbamazepine-10, 11-epoxide

F. Pisani, C. Artesi, R. Trio, F. Romano, C. Martines, E. Spina, E. Perucca, L. Bertilsson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of viloxazine (300 mg daily) on the pharmacokinetics of carbamazepine-10,11-epoxide (CBZ-E) the active metabolite of carbamazepine, was investigated in five healthy volunteers. Viloxazine treatment caused a slight but significant prolongation of CBZ-E half-life from 6.7 ± 0.6 to 8.9 ± 1.2 h (Mean values ± S.D. p <0.05), while the other kinetic parameters of CBZ-E were not significantly affected. These preliminary findings suggest that viloxazine inhibits the hepatic metabolism of CBZ-E.

Original languageItalian
Title of host publicationBollettino - Lega Italiana contro l'Epilessia
Pages353-354
Number of pages2
Edition66-67
Publication statusPublished - 1989

Fingerprint

Viloxazine
Pharmacokinetics
Carbamazepine
Half-Life
Healthy Volunteers
Liver
carbamazepine epoxide
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Pisani, F., Artesi, C., Trio, R., Romano, F., Martines, C., Spina, E., ... Bertilsson, L. (1989). EFFETTO DELLA VILOXAZINA SULLA FARMACOCINETICA DELL'EPOSSIDO DELLA CARBAMAZEPINA. In Bollettino - Lega Italiana contro l'Epilessia (66-67 ed., pp. 353-354)

EFFETTO DELLA VILOXAZINA SULLA FARMACOCINETICA DELL'EPOSSIDO DELLA CARBAMAZEPINA. / Pisani, F.; Artesi, C.; Trio, R.; Romano, F.; Martines, C.; Spina, E.; Perucca, E.; Bertilsson, L.

Bollettino - Lega Italiana contro l'Epilessia. 66-67. ed. 1989. p. 353-354.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pisani, F, Artesi, C, Trio, R, Romano, F, Martines, C, Spina, E, Perucca, E & Bertilsson, L 1989, EFFETTO DELLA VILOXAZINA SULLA FARMACOCINETICA DELL'EPOSSIDO DELLA CARBAMAZEPINA. in Bollettino - Lega Italiana contro l'Epilessia. 66-67 edn, pp. 353-354.
Pisani F, Artesi C, Trio R, Romano F, Martines C, Spina E et al. EFFETTO DELLA VILOXAZINA SULLA FARMACOCINETICA DELL'EPOSSIDO DELLA CARBAMAZEPINA. In Bollettino - Lega Italiana contro l'Epilessia. 66-67 ed. 1989. p. 353-354
Pisani, F. ; Artesi, C. ; Trio, R. ; Romano, F. ; Martines, C. ; Spina, E. ; Perucca, E. ; Bertilsson, L. / EFFETTO DELLA VILOXAZINA SULLA FARMACOCINETICA DELL'EPOSSIDO DELLA CARBAMAZEPINA. Bollettino - Lega Italiana contro l'Epilessia. 66-67. ed. 1989. pp. 353-354
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