EFFETTO DELLA VILOXAZINA SULLA FARMACOCINETICA DELL'EPOSSIDO DELLA CARBAMAZEPINA

Translated title of the contribution: Effect of viloxazine on the pharmacokinetics of carbamazepine-10, 11-epoxide

F. Pisani, C. Artesi, R. Trio, F. Romano, C. Martines, E. Spina, E. Perucca, L. Bertilsson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of viloxazine (300 mg daily) on the pharmacokinetics of carbamazepine-10,11-epoxide (CBZ-E) the active metabolite of carbamazepine, was investigated in five healthy volunteers. Viloxazine treatment caused a slight but significant prolongation of CBZ-E half-life from 6.7 ± 0.6 to 8.9 ± 1.2 h (Mean values ± S.D. p <0.05), while the other kinetic parameters of CBZ-E were not significantly affected. These preliminary findings suggest that viloxazine inhibits the hepatic metabolism of CBZ-E.

Translated title of the contributionEffect of viloxazine on the pharmacokinetics of carbamazepine-10, 11-epoxide
Original languageItalian
Title of host publicationBollettino - Lega Italiana contro l'Epilessia
Pages353-354
Number of pages2
Edition66-67
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Clinical Neurology

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