Effect of vincristine on bone marrow cells of patients with multiple myeloma - A cytokinetic study

Alberto Riccardi, Agostino Martinotti, Carlo Maurizio Montecucco, Giuliano Mazzini, Paolo Giordano

Research output: Contribution to journalArticle

Abstract

The cytokinetic changes induced by Vincristine (VCR) on bone marrow erythroblasts, myeloid cells and neoplastic plasma cells have been studied in four patients with plasma cell malignancies using combined DNA cytofluorometry and in vitro tritiated thymidine cytoautoradiography. The changes observed 9 h after the administration of the drug were in accordance with its S-phase specificity. The magnitude of the stathmokinetic effect was in fact roughly proportional to the proliferative activity of the different cell lines, i.e., marked on the erythroblasts, less evident on the myeloid cells and still lower on the plasma cells. In this last cell population VCR has also blocked or partially impaired the DNA synthesis. Nine days after VCR, the plasma cells were recruited into the proliferative cycle while the regeneration of the hemopoietic cells was already exhausted. Repeated administrations of VCR spaced at about 9 day intervals are more and more effective on the plasma cell population, since the S phase specificity of the drug against the recruited plasma cells is potentiated. On the contrary, the regeneration of the hemopoietic cells is protected by this time interval.

Original languageEnglish
Pages (from-to)239-248
Number of pages10
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume35
Issue number1
DOIs
Publication statusPublished - Dec 1980

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Keywords

  • Cytoautoradiography
  • DNA cytofluorometry
  • Myeloma
  • Vincristine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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