Effect of voluntary repetitive long-lasting muscle contraction activity on the BOLD signal as assessed by optimal hemodynamic response function

Silvia Francesca Storti, Emanuela Formaggio, Deborah Moretto, Alessandra Bertoldo, Francesca Benedetta Pizzini, Alberto Beltramello, Antonio Fiaschi, Gianna Maria Toffolo, Paolo Manganotti

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Among other neuroimaging techniques, functional magnetic resonance imaging (fMRI) can be useful for studying the development of motor fatigue. The aim of this study was to identify differences in cortical neuronal activation in nine subjects on three motor tasks: right-hand movement with minimum, maximum, and post-fatigue maximum finger flexion. Materials and methods: fMRI activation maps for each subject and during each condition were obtained by estimating the optimal model of the hemodynamic response function (HRF) out of four standard HRF models and an individual-based HRF model (ibHRF). Results: ibHRF was selected as the optimal model in six out of nine subjects for minimum movement, in five out of nine for maximum movement, and in eight out of nine for post-fatigue maximum movement. As compared to maximum movement, a large reduction in the total number of active voxels (primary sensorimotor area, supplementary motor area and cerebellum) was observed in post-fatigue maximum movement. Conclusion: This is the first approach to the evaluation of long-lasting contraction effort in healthy subjects by means of the fMRI paradigm with the use of an individual-based hemodynamic response. The results may be relevant for defining a baseline in future studies on central fatigue in patients with neuropathological disorders.

Original languageEnglish
Pages (from-to)171-184
Number of pages14
JournalMagnetic Resonance Materials in Physics, Biology, and Medicine
Volume27
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Fatigue
  • FMRI
  • Hemodynamic response function
  • Long-lasting muscle contraction activity
  • Motor cortex

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of 'Effect of voluntary repetitive long-lasting muscle contraction activity on the BOLD signal as assessed by optimal hemodynamic response function'. Together they form a unique fingerprint.

Cite this