Effect of X-irradiation on liver regeneration

Enrico Clerici, Piero Cammarano, Paolo Mocarelli

Research output: Contribution to journalArticlepeer-review

Abstract

The in vivo incorporation of dl-Leucine-1-14C into the total protein and the protein of cell fractions in liver of partially hepatectomized rats, given a whole-body X-irradiation 4 hr after surgery (i.e., within the so-called presynthetic period of liver regeneration) was investigated. The main feature of our results indicates that the whole-body X-irradiation inhibits the incorporation of labeled aminoacid into the soluble, nuclear, and microsomal fractions of regenerating liver as compared with unirradiated partially hepatectomized control rats. On the basis of recent information on the mechanism of protein synthesis, such data are tentatively explained as resulting from disturbance in the synthesis or turnover of nuclear RNA's acting as templates in the production of the new protein molecules necessary to support liver regeneration.

Original languageEnglish
Pages (from-to)389-395
Number of pages7
JournalExperimental and Molecular Pathology
Volume5
Issue number4
Publication statusPublished - Aug 1966

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

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