Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers

Ronnie D'Amico, Ligia A. Pinto, Peter Meyer, Alan L. Landay, Alan A. Harris, Mario Clerici, Jay A. Berzofsky, Gene M. Shearer, Harold A. Kessler

Research output: Contribution to journalArticle


We evaluated the effects of zidovudine postexposure prophylaxis (PEP) on the development of human immunodeficiency virus (HIV) envelope-specific cytotoxic T-lymphocyte responses in 20 healthcare workers with occupational exposures to HIV. Seven healthcare workers were treated with zidovudine PEP. Only 1 of 7 treated, versus 6 of 13 not treated, developed an HIV envelope-specific cytotoxic T-lymphocyte response. These data suggest that zidovudine abrogated HIV-specific cytotoxic T-lymphocyte responses. HIV-specific cytotoxic T-lymphocyte responses may be useful as a surrogate marker of HIV replication in the evaluation of new regimens for PEP of occupational HIV exposures.

Original languageEnglish
Pages (from-to)428-430
Number of pages3
JournalInfection Control and Hospital Epidemiology
Issue number6
Publication statusPublished - 1999


ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

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