Effect on platelet functions of derivatives of cyclic nucleotides

F. I. Pareti, D. Carrera, L. Mannucci, P. M. Mannucci

Research output: Contribution to journalArticlepeer-review

Abstract

Derivatives of cyclic nucleotides were evaluated for their ability to inhibit platelet aggregation and the release reaction. Derivatives substituted in position 8 (mainly 8-Br-cyclic GMP) were more active than 3'-5' cyclic AMP, and their relative potency in inhibiting platelet aggregation and 14C-serotonin release was comparable to that of N62-0'-dibutyryl-cyclic AMP. Compounds substituted in position 6 or 2'-0 were not effective. The active compounds, which were also tested for their ability to stimulate platelet adenylate cyclase or to inhibit cyclic AMP phosphodiesterase, did not modify the intracellular levels of cyclic AMP. Since previous animal experiments have shown that these derivatives cause less side effects than cyclic AMP and its dibutyryl derivative in animals, it is suggested that modification of the cyclophosphate molecule might make it possible to find compounds active only on platelet function without interfering with other biological systems.

Original languageEnglish
Pages (from-to)404-410
Number of pages7
JournalThrombosis and Haemostasis
Volume39
Issue number2
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Hematology

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