Abstract
Transforming growth factor-β canceled the hepatocyte proliferation caused by transforming growth factor-α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast, transforming growth factor-β had no antidotal action on the stimulatory effects of insulin or full test doses of insulinlike factor-2, hepatocyte growth factor, epidermal growth factor or triiodothymanine. A minor antidotal effect on hepatic stimulatory substance activity could be detected, but only with hepatic stimulatory substance was given in doses smaller than those known to cause maximum stimulatory response. These results suggest a highly specific pharmacological and physiological interaction between transforming growth factor-α and transforming growth factor-β in the modulation of liver growth control.
| Original language | English |
|---|---|
| Pages (from-to) | 1267-1270 |
| Number of pages | 4 |
| Journal | Hepatology |
| Volume | 16 |
| Issue number | 5 |
| Publication status | Published - Nov 1992 |
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ASJC Scopus subject areas
- Hepatology
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Effect on the canine Eck fistula liver of intraportal TGF-β alone or with hepatic growth factors. / Francavilla, Antonio; Azzarone, Alessandro; Carrieri, Guiseppe; Scotti-Foglieni, Carlo; Zeng, Qia Hua; Cillo, Umberto; Porter, Kendrick; Starzl, Thomas E.
In: Hepatology, Vol. 16, No. 5, 11.1992, p. 1267-1270.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect on the canine Eck fistula liver of intraportal TGF-β alone or with hepatic growth factors
AU - Francavilla, Antonio
AU - Azzarone, Alessandro
AU - Carrieri, Guiseppe
AU - Scotti-Foglieni, Carlo
AU - Zeng, Qia Hua
AU - Cillo, Umberto
AU - Porter, Kendrick
AU - Starzl, Thomas E.
PY - 1992/11
Y1 - 1992/11
N2 - Transforming growth factor-β canceled the hepatocyte proliferation caused by transforming growth factor-α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast, transforming growth factor-β had no antidotal action on the stimulatory effects of insulin or full test doses of insulinlike factor-2, hepatocyte growth factor, epidermal growth factor or triiodothymanine. A minor antidotal effect on hepatic stimulatory substance activity could be detected, but only with hepatic stimulatory substance was given in doses smaller than those known to cause maximum stimulatory response. These results suggest a highly specific pharmacological and physiological interaction between transforming growth factor-α and transforming growth factor-β in the modulation of liver growth control.
AB - Transforming growth factor-β canceled the hepatocyte proliferation caused by transforming growth factor-α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast, transforming growth factor-β had no antidotal action on the stimulatory effects of insulin or full test doses of insulinlike factor-2, hepatocyte growth factor, epidermal growth factor or triiodothymanine. A minor antidotal effect on hepatic stimulatory substance activity could be detected, but only with hepatic stimulatory substance was given in doses smaller than those known to cause maximum stimulatory response. These results suggest a highly specific pharmacological and physiological interaction between transforming growth factor-α and transforming growth factor-β in the modulation of liver growth control.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026456966&partnerID=8YFLogxK
M3 - Article
C2 - 1427665
AN - SCOPUS:0026456966
VL - 16
SP - 1267
EP - 1270
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 5
ER -