Effect on the development of ankle edema of adding delapril to manidipine in patients with mild to moderate essential hypertension: A three-way crossover study

Roberto Fogari, GianDomenico Malamani, Annalisa Zoppi, Amedeo Mugellini, Andrea Rinaldi, Elena Fogari, Tiziano Perrone

Research output: Contribution to journalArticle

Abstract

Background: Use of the combination of an angiotensinconverting enzyme inhibitor (ACEI) and a calcium channel blocker (CCB) is considered a rational approach in patients whose hypertension is not controlled by monotherapy, providing better blood pressure (BP) control than the individual components with a lower incidence of adverse effects. In particular, such combinations have been found to reduce the incidence of ankle edema, the most common adverse effect of dihydropyridine annhypertensives. Objective: The present study was undertaken to evaluate the effect on the development of ankle edema of adding the ACEI delapril to the CCB manidipine in patients with mild to moderate essential hypertension. Methods: Patients between the ages of 30 and 70 years who had mild to moderate hypertension (diastolic BP [DBP] >90 and

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalClinical Therapeutics
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • ankle edema
  • combination treatment
  • delapril
  • manidipine

ASJC Scopus subject areas

  • Pharmacology

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