Effective mobilization of Philadelphia-chromosome-negative cells in chronic myelogenous leukaemia patients using a less intensive regimen

Angelo M. Carella, Enrica Lerma, Lidia Celesti, Anna Dejana, Zikos Panagiotis, Maria Teresa Corsetti, Francesco Frassoni

Research output: Contribution to journalArticle

Abstract

To determine if reducing the intensity of the mobilizing chemotherapy protocol used would alter the number and/or quality of the progenitors mobilized in patients with chronic myelogenous leukaemia (CML), we undertook a pilot study. 36 consecutive CML patients previously treated only with hydroxyurea were given mobilization therapy within 12 months of diagnosis. 17 patients were treated by the ICE protocol and 18 patients received the mini- ICE protocol. The leukapheresis product collected from 22/36 patients (62%) was entirely Ph-negative. The cytogenetic results between ICE and mini-ICE- treated protocols were not significant, although the reduction in median days of hospitalization required for the mini-ICE versus the ICE protocol was highly significant (P+ cells and CFU-GM collected. No patient in the mini-ICE protocol experienced high-grade oral mucositis and GI toxicity whereas three such cased mobilization procedure in wither group.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalBritish Journal of Haematology
Volume100
Issue number2
DOIs
Publication statusPublished - 1998

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Keywords

  • Cytogenetic response
  • Early untreated CML
  • ICE protocol
  • mini-ICE protocol
  • Reduced toxicity

ASJC Scopus subject areas

  • Hematology

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