Effective proliferation control of human cancer cells using electrical pulses

Raji Sundararajan, Funian Xiao, Therese Salameh, Lisa Reece, James F. Leary, Kevin Otto, Ignacio Camarillo, Luca G. Campana

Research output: Contribution to journalArticlepeer-review

Abstract

Since current cancer therapies do not work effectively for all patients, there is a pressing need for alternate, affordable, yet effective treatments for inoperable and chemo-resistant tumors. Presented in this paper are our investigations on the application of short duration (milli and micro seconds) electrical voltage pulses for the treatment of breast carcinoma. For this purpose, electroporation, a pulse power technology, was evaluated for its effect upon the viability and proliferation of human breast cancer cells using a number of voltages and pulse durations. The results indicate the promising potential of electrical pulses to effectively and economically enhance drug transport across the normally impermeable plasma cell membranes and to reduce proliferation.

Original languageEnglish
Article number6396984
Pages (from-to)2225-2236
Number of pages12
JournalIEEE Transactions on Dielectrics and Electrical Insulation
Volume19
Issue number6
DOIs
Publication statusPublished - 2012

Keywords

  • Electroporation
  • flow cytometry
  • impedance spectroscopy
  • MCF-7 breast cancer cell line
  • proliferation control
  • western blot

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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