Effectiveness and complications of vascular access closure devices after interventional procedures

Marco Sesana, Marco Vaghetti, Remo Albiero, Nicola Corvaja, Giovanni Martini, Ginevra Sivieri, Antonio Colombo

Research output: Contribution to journalArticlepeer-review


Background. Vascular closure devices are designed to obtain a fast hemostasis of the vascular access site after diagnostic and interventional procedures. This result should be obtained with a low incidence of complications. Methods. A retrospective, non-randomized study was performed to evaluate the success rate and vascular complications associated with the use of two different vascular sealing devices [Angio-Seal (Daig Corporation, Minnetonka, Minnesota) and Prostar (Perclose, Inc., Redwood City, California)] after interventional procedures. Results. Eight hundred and twenty-seven devices were used (245 Angio-Seal and 582 Prostar). Angio-Seal success rate was 92% with a 2.5% rate of vascular complications; Prostar success rate was 89% with a 3.4% rate of vascular complications. Multivariate logistic regression analysis identified advanced age (p <0.05) and lower weight (p <0.05) as independent predictors of vascular complications associated with Angio-Seal use, while diabetes (p <0.05) was found to be a predictor of vascular complications in the Prostar group. Abciximab use and larger sheath size were not associated with an increased probability of vascular complications. Conclusion. Angio-Seal and Prostar obtain a fast vascular access hemostasis after interventional procedures, with a low incidence of major vascular complications.

Original languageEnglish
Pages (from-to)395-399
Number of pages5
JournalJournal of Invasive Cardiology
Issue number8
Publication statusPublished - Aug 2000


  • Hemostasis
  • Percutaneous transluminal coronary angioplasty
  • Peripheral vascular complications
  • Vascular closure devices

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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