Effectiveness and limitations of β-blocker therapy in congenital long- QT syndrome

Arthur J. Moss, Wojciech Zareba, W. Jackson Hall, Peter J. Schwartz, Richard S. Crampton, Jesaia Benhorin, G. Michael Vincent, Emanuela H. Locati, Silvia G. Priori, Carlo Napolitano, Aharon Medina, Li Zhang, Jennifer L. Robinson, Katherine Timothy, Jeffrey A. Towbin, Mark L. Andrews

Research output: Contribution to journalArticlepeer-review

Abstract

Background - β-blockers are routinely prescribed in congenital long-QT syndrome (LQTS), but the effectiveness ant limitations of β-blockers in this disorder have not been evaluated. Methods and Results - The study population comprised 869 LQTS patients treated with β-blockers. Effectiveness of β- blockers was analyzed during matched periods before and after starting β- blocker therapy, and by survivorship methods to determine factors associated with cardiac events while on prescribed β-blockers. After initiation of β- blockers, there was a significant (P

Original languageEnglish
Pages (from-to)616-623
Number of pages8
JournalCirculation
Volume101
Issue number6
Publication statusPublished - Feb 15 2000

Keywords

  • Arrhythmia
  • Death, sudden
  • Heart arrest
  • Long-QT syndrome
  • Syncope

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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