Effectiveness and safety of cyclosporine in pediatric plaque psoriasis: A multicentric retrospective analysis

V. Di Lernia, L. Stingeni, V. Boccaletti, P. G. Calzavara Pinton, C. Guarneri, Anna Belloni Fortina, M. Panzone, M. Corazza, I. Neri, S. Cambiaghi, C. Lasagni, E. Ficarelli, P. Gisondi

Research output: Contribution to journalArticle

Abstract

Background: Cyclosporine (CysA) is effective for psoriasis in adult patients but little data exist about its efficacy and safety in childhood and adolescence psoriasis. Objectives: To assess the effectiveness and safety of CysA for childhood and adolescence psoriasis. Methods: Retrospective analysis of a group of children and adolescents (age <17 years) with plaque psoriasis treated with CysA at several Italian dermatology clinics. Results: Our study population consisted of 38 patients. The median age at the start of treatment was 12.3 years. Therapy duration varied from one to 36 months. The median maintenance dosage per day was 3.2 mg/kg (range 2–5 mg/kg). Fifteen patients (39,4%) achieved a complete clearance or a good improvement of their psoriasis defined by an improvement from baseline of ≥75% in the psoriasis area and severity index (PASI) at week 16. Eight patients (21.05%) discontinued the treatment due to laboratory anomalies or adverse events. Serious events were not recorded. Conclusions: In this case series, CysA was effective and well-tolerated treatment in a significant quote of children. CysA, when carefully monitored, may represent a therapeutic alternative to the currently used systemic immunosuppressive agents for severe childhood psoriasis. © 2015 Informa UK Limited, trading as Taylor & Francis Group.
Original languageEnglish
Pages (from-to)395-398
Number of pages4
JournalJournal of Dermatological Treatment
Volume27
Issue number5
DOIs
Publication statusPublished - 2016

Cite this

Di Lernia, V., Stingeni, L., Boccaletti, V., Calzavara Pinton, P. G., Guarneri, C., Belloni Fortina, A., ... Gisondi, P. (2016). Effectiveness and safety of cyclosporine in pediatric plaque psoriasis: A multicentric retrospective analysis. Journal of Dermatological Treatment, 27(5), 395-398. https://doi.org/10.3109/09546634.2015.1120852

Effectiveness and safety of cyclosporine in pediatric plaque psoriasis: A multicentric retrospective analysis. / Di Lernia, V.; Stingeni, L.; Boccaletti, V.; Calzavara Pinton, P. G.; Guarneri, C.; Belloni Fortina, Anna; Panzone, M.; Corazza, M.; Neri, I.; Cambiaghi, S.; Lasagni, C.; Ficarelli, E.; Gisondi, P.

In: Journal of Dermatological Treatment, Vol. 27, No. 5, 2016, p. 395-398.

Research output: Contribution to journalArticle

Di Lernia, V, Stingeni, L, Boccaletti, V, Calzavara Pinton, PG, Guarneri, C, Belloni Fortina, A, Panzone, M, Corazza, M, Neri, I, Cambiaghi, S, Lasagni, C, Ficarelli, E & Gisondi, P 2016, 'Effectiveness and safety of cyclosporine in pediatric plaque psoriasis: A multicentric retrospective analysis', Journal of Dermatological Treatment, vol. 27, no. 5, pp. 395-398. https://doi.org/10.3109/09546634.2015.1120852
Di Lernia, V. ; Stingeni, L. ; Boccaletti, V. ; Calzavara Pinton, P. G. ; Guarneri, C. ; Belloni Fortina, Anna ; Panzone, M. ; Corazza, M. ; Neri, I. ; Cambiaghi, S. ; Lasagni, C. ; Ficarelli, E. ; Gisondi, P. / Effectiveness and safety of cyclosporine in pediatric plaque psoriasis: A multicentric retrospective analysis. In: Journal of Dermatological Treatment. 2016 ; Vol. 27, No. 5. pp. 395-398.
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abstract = "Background: Cyclosporine (CysA) is effective for psoriasis in adult patients but little data exist about its efficacy and safety in childhood and adolescence psoriasis. Objectives: To assess the effectiveness and safety of CysA for childhood and adolescence psoriasis. Methods: Retrospective analysis of a group of children and adolescents (age <17 years) with plaque psoriasis treated with CysA at several Italian dermatology clinics. Results: Our study population consisted of 38 patients. The median age at the start of treatment was 12.3 years. Therapy duration varied from one to 36 months. The median maintenance dosage per day was 3.2 mg/kg (range 2–5 mg/kg). Fifteen patients (39,4{\%}) achieved a complete clearance or a good improvement of their psoriasis defined by an improvement from baseline of ≥75{\%} in the psoriasis area and severity index (PASI) at week 16. Eight patients (21.05{\%}) discontinued the treatment due to laboratory anomalies or adverse events. Serious events were not recorded. Conclusions: In this case series, CysA was effective and well-tolerated treatment in a significant quote of children. CysA, when carefully monitored, may represent a therapeutic alternative to the currently used systemic immunosuppressive agents for severe childhood psoriasis. {\circledC} 2015 Informa UK Limited, trading as Taylor & Francis Group.",
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T1 - Effectiveness and safety of cyclosporine in pediatric plaque psoriasis: A multicentric retrospective analysis

AU - Di Lernia, V.

AU - Stingeni, L.

AU - Boccaletti, V.

AU - Calzavara Pinton, P. G.

AU - Guarneri, C.

AU - Belloni Fortina, Anna

AU - Panzone, M.

AU - Corazza, M.

AU - Neri, I.

AU - Cambiaghi, S.

AU - Lasagni, C.

AU - Ficarelli, E.

AU - Gisondi, P.

N1 - Export Date: 29 March 2017

PY - 2016

Y1 - 2016

N2 - Background: Cyclosporine (CysA) is effective for psoriasis in adult patients but little data exist about its efficacy and safety in childhood and adolescence psoriasis. Objectives: To assess the effectiveness and safety of CysA for childhood and adolescence psoriasis. Methods: Retrospective analysis of a group of children and adolescents (age <17 years) with plaque psoriasis treated with CysA at several Italian dermatology clinics. Results: Our study population consisted of 38 patients. The median age at the start of treatment was 12.3 years. Therapy duration varied from one to 36 months. The median maintenance dosage per day was 3.2 mg/kg (range 2–5 mg/kg). Fifteen patients (39,4%) achieved a complete clearance or a good improvement of their psoriasis defined by an improvement from baseline of ≥75% in the psoriasis area and severity index (PASI) at week 16. Eight patients (21.05%) discontinued the treatment due to laboratory anomalies or adverse events. Serious events were not recorded. Conclusions: In this case series, CysA was effective and well-tolerated treatment in a significant quote of children. CysA, when carefully monitored, may represent a therapeutic alternative to the currently used systemic immunosuppressive agents for severe childhood psoriasis. © 2015 Informa UK Limited, trading as Taylor & Francis Group.

AB - Background: Cyclosporine (CysA) is effective for psoriasis in adult patients but little data exist about its efficacy and safety in childhood and adolescence psoriasis. Objectives: To assess the effectiveness and safety of CysA for childhood and adolescence psoriasis. Methods: Retrospective analysis of a group of children and adolescents (age <17 years) with plaque psoriasis treated with CysA at several Italian dermatology clinics. Results: Our study population consisted of 38 patients. The median age at the start of treatment was 12.3 years. Therapy duration varied from one to 36 months. The median maintenance dosage per day was 3.2 mg/kg (range 2–5 mg/kg). Fifteen patients (39,4%) achieved a complete clearance or a good improvement of their psoriasis defined by an improvement from baseline of ≥75% in the psoriasis area and severity index (PASI) at week 16. Eight patients (21.05%) discontinued the treatment due to laboratory anomalies or adverse events. Serious events were not recorded. Conclusions: In this case series, CysA was effective and well-tolerated treatment in a significant quote of children. CysA, when carefully monitored, may represent a therapeutic alternative to the currently used systemic immunosuppressive agents for severe childhood psoriasis. © 2015 Informa UK Limited, trading as Taylor & Francis Group.

KW - childhood

KW - cyclosporine

KW - Psoriasis

KW - therapy

KW - treatment

U2 - 10.3109/09546634.2015.1120852

DO - 10.3109/09546634.2015.1120852

M3 - Article

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