Effectiveness and safety of sirolimus-eluting stents in the treatment of restenosis after coronary stent placement

Franz Josef Neumann, Walter Desmet, Eberhard Grube, Johannes Brachmann, Patrizia Presbitero, Paolo Rubartelli, Andreas Mügge, Francesco Di Pede, Diana Füllgraf, Wim Aengevaeren, Leonardo Spedicato, Jeffrey J. Popma

Research output: Contribution to journalArticle

Abstract

Background-In-stent restenosis is notoriously difficult to treat by repeat catheter intervention because of its propensity for aggressive recurrent neointimal formation. This study sought to assess the effectiveness and safety of the sirolimus-eluting stent in the treatment of in-stent restenosis. Methods and Results-The study was designed as a prospective multicenter registry. We included 162 patients with in-stent restenosis of a native coronary artery who had a clinical indication for repeat intervention. Patients were scheduled for follow-up angiography at 6 months. The primary end point was in-lesion late loss. Follow-up angiography was performed in 155 patients. We obtained an in-lesion late loss of 0.08±0.49 mm and a binary restenosis rate of 9.7% (15/155), which prompted reintervention in 7.4% (12/162) at 9 months. The 9-month rate of death was 1.2% (2/162) and that of nonfatal myocardial infarction was 1.2% (2/162). Conclusions-Sirolimus-eluting stents were highly efficacious and safe in the treatment of in-stent restenosis. Our study provides rationale for the use of sirolimus-eluting stents in the treatment of in-stent restenosis.

Original languageEnglish
Pages (from-to)2107-2111
Number of pages5
JournalCirculation
Volume111
Issue number16
DOIs
Publication statusPublished - Apr 26 2005

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Keywords

  • Restenosis
  • Sirolimus
  • Stents

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Neumann, F. J., Desmet, W., Grube, E., Brachmann, J., Presbitero, P., Rubartelli, P., Mügge, A., Di Pede, F., Füllgraf, D., Aengevaeren, W., Spedicato, L., & Popma, J. J. (2005). Effectiveness and safety of sirolimus-eluting stents in the treatment of restenosis after coronary stent placement. Circulation, 111(16), 2107-2111. https://doi.org/10.1161/01.CIR.0000162467.53001.6B