Effectiveness and safety of the angiotensin II antagonist irbesartan in children with chronic kidney diseases

L. M D Franscini, Rodo O. Von Vigier, Roger Pfister, Carmen Casaulta-Aebischer, Emilio Fossali, Mario G. Bianchetti

Research output: Contribution to journalArticle

Abstract

Background: Studies in adults with chronic kidney diseases demonstrate that the orally available angiotensin II antagonist irbesartan reduces arterial pressure and pathological proteinuria, mostly with an excellent tolerability profile. Little information is available on irbesartan in childhood. Methods: A total of 44 pediatric outpatients with chronic kidney disease (27 male and 17, aged 3.7 to 18 years, median 10 years) were given irbesartan once a day during 18 weeks for arterial hypertension (N = 23), proteinuria (N = 8), or both (N = 13). Results: In patients with hypertension, the use of irbesartan 4.1 (3.1-5.3) mg/kg body weight daily (median and interquartile range) was associated with a decrease (P <.005) in arterial pressure by 17 (13-22)/10 (7-12) mm Hg. In patients with overt proteinuria the urinary protein excretion decreased (P <.01) during treatment with irbesartan (2.9 [2.0-4.8] mg/kg body weight) by 52 (0-75) mg/[m2 × h]), whereas plasma albumin increased (P <.05) by 4 (1-5) g/L. The frequency of abdominal pain, constipation, cough, diarrhea, dizziness, edema, fatigue, headache, insomnia, myalgia, orthostasis, and rash was similar before and with irbesartan. Plasma sodium slightly decreased, whereas plasma potassium increased, with irbesartan (P <.01). Conclusions: In pediatric patients with chronic kidney diseases, irbesartan given once a day for 18 weeks significantly reduces arterial pressure and proteinuria, with an excellent tolerability and side effect profile. Am J Hypertens 2002;15:1057-1063

Original languageEnglish
Pages (from-to)1057-1063
Number of pages7
JournalAmerican Journal of Hypertension
Volume15
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

Keywords

  • Childhood
  • Chronic kidney disease
  • Hypertension
  • Irbesartan
  • Proteinuria

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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