Effectiveness of α-fetoprotein for hepatocellular carcinoma surveillance

The return of the living-dead?

Edoardo G. Giannini, Virginia Erroi, Franco Trevisani

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Evaluation of: Singal AG, Conjeevaram HS, Volk ML et al. Effectiveness of hepatocellular surveillance in patients with cirrhosis. Cancer Epidemiol. Biomarkers Prev. 21(5), 793-799 (2012). The evaluated article assesses the effectiveness in clinical practice of surveillance with ultrasound (US) and α-fetoprotein (AFP) in patients at risk of developing hepatocellular carcinoma. After a median follow-up of 3.5 years, among the 442 enrolled patients with cirrhosis, 41 developed tumor (annual incidence, 2.8%). Twenty-three hepatocellular carcinomas were diagnosed at Barcelona Clinic Liver Cancer early stage (single tumor 20ng/ml. Specificity was 91.5% for US and 90.5% for AFP. The combination of the tests increased the sensitivity to 90.2%, with a small decrease in specificity (83.3%). In a real-world setting, the combination of US and AFP would be the most effective for hepatocellular carcinoma surveillance.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalExpert Review of Gastroenterology and Hepatology
Volume6
Issue number4
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Fetal Proteins
Hepatocellular Carcinoma
Fibrosis
Neoplasms
Liver Neoplasms
Biomarkers
Incidence

Keywords

  • α-fetoprotein
  • cirrhosis
  • diagnosis
  • hepatocellular carcinoma
  • surveillance
  • ultrasonography

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Effectiveness of α-fetoprotein for hepatocellular carcinoma surveillance : The return of the living-dead? / Giannini, Edoardo G.; Erroi, Virginia; Trevisani, Franco.

In: Expert Review of Gastroenterology and Hepatology, Vol. 6, No. 4, 08.2012, p. 441-444.

Research output: Contribution to journalArticle

@article{10474ed802c94c6fb520f0994009a1ac,
title = "Effectiveness of α-fetoprotein for hepatocellular carcinoma surveillance: The return of the living-dead?",
abstract = "Evaluation of: Singal AG, Conjeevaram HS, Volk ML et al. Effectiveness of hepatocellular surveillance in patients with cirrhosis. Cancer Epidemiol. Biomarkers Prev. 21(5), 793-799 (2012). The evaluated article assesses the effectiveness in clinical practice of surveillance with ultrasound (US) and α-fetoprotein (AFP) in patients at risk of developing hepatocellular carcinoma. After a median follow-up of 3.5 years, among the 442 enrolled patients with cirrhosis, 41 developed tumor (annual incidence, 2.8{\%}). Twenty-three hepatocellular carcinomas were diagnosed at Barcelona Clinic Liver Cancer early stage (single tumor 20ng/ml. Specificity was 91.5{\%} for US and 90.5{\%} for AFP. The combination of the tests increased the sensitivity to 90.2{\%}, with a small decrease in specificity (83.3{\%}). In a real-world setting, the combination of US and AFP would be the most effective for hepatocellular carcinoma surveillance.",
keywords = "α-fetoprotein, cirrhosis, diagnosis, hepatocellular carcinoma, surveillance, ultrasonography",
author = "Giannini, {Edoardo G.} and Virginia Erroi and Franco Trevisani",
year = "2012",
month = "8",
doi = "10.1586/egh.12.30",
language = "English",
volume = "6",
pages = "441--444",
journal = "Expert Review of Gastroenterology and Hepatology",
issn = "1747-4124",
publisher = "Expert Reviews Ltd.",
number = "4",

}

TY - JOUR

T1 - Effectiveness of α-fetoprotein for hepatocellular carcinoma surveillance

T2 - The return of the living-dead?

AU - Giannini, Edoardo G.

AU - Erroi, Virginia

AU - Trevisani, Franco

PY - 2012/8

Y1 - 2012/8

N2 - Evaluation of: Singal AG, Conjeevaram HS, Volk ML et al. Effectiveness of hepatocellular surveillance in patients with cirrhosis. Cancer Epidemiol. Biomarkers Prev. 21(5), 793-799 (2012). The evaluated article assesses the effectiveness in clinical practice of surveillance with ultrasound (US) and α-fetoprotein (AFP) in patients at risk of developing hepatocellular carcinoma. After a median follow-up of 3.5 years, among the 442 enrolled patients with cirrhosis, 41 developed tumor (annual incidence, 2.8%). Twenty-three hepatocellular carcinomas were diagnosed at Barcelona Clinic Liver Cancer early stage (single tumor 20ng/ml. Specificity was 91.5% for US and 90.5% for AFP. The combination of the tests increased the sensitivity to 90.2%, with a small decrease in specificity (83.3%). In a real-world setting, the combination of US and AFP would be the most effective for hepatocellular carcinoma surveillance.

AB - Evaluation of: Singal AG, Conjeevaram HS, Volk ML et al. Effectiveness of hepatocellular surveillance in patients with cirrhosis. Cancer Epidemiol. Biomarkers Prev. 21(5), 793-799 (2012). The evaluated article assesses the effectiveness in clinical practice of surveillance with ultrasound (US) and α-fetoprotein (AFP) in patients at risk of developing hepatocellular carcinoma. After a median follow-up of 3.5 years, among the 442 enrolled patients with cirrhosis, 41 developed tumor (annual incidence, 2.8%). Twenty-three hepatocellular carcinomas were diagnosed at Barcelona Clinic Liver Cancer early stage (single tumor 20ng/ml. Specificity was 91.5% for US and 90.5% for AFP. The combination of the tests increased the sensitivity to 90.2%, with a small decrease in specificity (83.3%). In a real-world setting, the combination of US and AFP would be the most effective for hepatocellular carcinoma surveillance.

KW - α-fetoprotein

KW - cirrhosis

KW - diagnosis

KW - hepatocellular carcinoma

KW - surveillance

KW - ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=84865756037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865756037&partnerID=8YFLogxK

U2 - 10.1586/egh.12.30

DO - 10.1586/egh.12.30

M3 - Article

VL - 6

SP - 441

EP - 444

JO - Expert Review of Gastroenterology and Hepatology

JF - Expert Review of Gastroenterology and Hepatology

SN - 1747-4124

IS - 4

ER -