Effectiveness of a 23-valent polysaccharide vaccine in preventing pneumonia and non-invasive pneumococcal infection in elderly people: A large-scale retrospective cohort study

F. Ansaldi, V. Turello, P. Lai, G. Batone, S. De Luca, R. Rosselli, P. Durando, L. Sticchi, R. Gasparini, E. Delfino, G. Icardi

Research output: Contribution to journalArticle

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Abstract

This retrospective cohort study evaluated the effectiveness of a 23-valent pneumococcal polysaccharide vaccine in reducing hospital admission for pneumonia, otitis media and exacerbation of asthma or other syndromes due to Streptococcus pneumoniae in 9170 high-risk individuals. Cohort members were followed from 1 January 1998 to 31 December 2002. With regard to preventing hospitalization due to pneumonia, we observed a decrease in the incidence of 1/10 000 person-months and a reduction in the relative risk of 38% in the vaccinated cohort compared with the non-vaccinated subjects. A decrease in the risk of hospital admission for asthma, acute otitis media, chronic obstructive pulmonary disease and other respiratory infections was also observed in vaccinated compared with non-vaccinated subjects. The specificity of these findings was confirmed by the lack of a protective effect from vaccination for those outcomes, such as hospitalization 'for all causes' and 'other otorhinolaryngological diagnoses', that were not directly related to pneumococcal disease.

Original languageEnglish
Pages (from-to)490-500
Number of pages11
JournalJournal of International Medical Research
Volume33
Issue number5
Publication statusPublished - Sep 2005

Fingerprint

Pneumococcal Infections
Polysaccharides
Pneumonia
Cohort Studies
Vaccines
Retrospective Studies
Otitis Media
Hospitalization
Asthma
Pulmonary diseases
Pneumococcal Vaccines
Streptococcus pneumoniae
Respiratory Tract Infections
Chronic Obstructive Pulmonary Disease
Vaccination
Incidence
23-valent pneumococcal capsular polysaccharide vaccine

Keywords

  • Elderly people
  • Non-invasive pneumococcal infections
  • Pneumococcal vaccine
  • Vaccine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effectiveness of a 23-valent polysaccharide vaccine in preventing pneumonia and non-invasive pneumococcal infection in elderly people : A large-scale retrospective cohort study. / Ansaldi, F.; Turello, V.; Lai, P.; Batone, G.; De Luca, S.; Rosselli, R.; Durando, P.; Sticchi, L.; Gasparini, R.; Delfino, E.; Icardi, G.

In: Journal of International Medical Research, Vol. 33, No. 5, 09.2005, p. 490-500.

Research output: Contribution to journalArticle

Ansaldi, F, Turello, V, Lai, P, Batone, G, De Luca, S, Rosselli, R, Durando, P, Sticchi, L, Gasparini, R, Delfino, E & Icardi, G 2005, 'Effectiveness of a 23-valent polysaccharide vaccine in preventing pneumonia and non-invasive pneumococcal infection in elderly people: A large-scale retrospective cohort study', Journal of International Medical Research, vol. 33, no. 5, pp. 490-500.
Ansaldi, F. ; Turello, V. ; Lai, P. ; Batone, G. ; De Luca, S. ; Rosselli, R. ; Durando, P. ; Sticchi, L. ; Gasparini, R. ; Delfino, E. ; Icardi, G. / Effectiveness of a 23-valent polysaccharide vaccine in preventing pneumonia and non-invasive pneumococcal infection in elderly people : A large-scale retrospective cohort study. In: Journal of International Medical Research. 2005 ; Vol. 33, No. 5. pp. 490-500.
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