Effectiveness of a bioabsorbable conduit in the repair of peripheral nerves

N. Nicoli Aldini, G. Perego, G. D. Cella, M. C. Maltarello, M. Fini, M. Rocca, R. Giardino

Research output: Contribution to journalArticlepeer-review

Abstract

A new conduit made with a bioabsorbable copolymer, poly(L-lactide-co-6-caprolactone), was evaluated in an animal model as a guide for nerve regeneration. The conduit had an inner diameter of 1.3 mm and a wall thickness of 175 μm. Segments of length 1.2 cm were interposed between the proximal and distal stumps of transected ischiatic nerves in Wistar rats, bridging a nerve gap of 1 cm. All of the procedure was performed under general anaesthesia using microsurgical techniques. Controls were performed at 1, 3 and 6 months and it was demonstrated that the conduit was still undamaged after 30 d. Progressive signs of degradation appeared at 90 and 180 d. Nerve regeneration in the lumen was effective as confirmed by histological and electron microscopical investigations. These preliminary results emphasize the interesting properties of the conduit with regard to the achievement of a neural prosthesis.

Original languageEnglish
Pages (from-to)959-962
Number of pages4
JournalBiomaterials
Volume17
Issue number10
DOIs
Publication statusPublished - May 1996

Keywords

  • Biomaterials
  • Microsurgery
  • Nerve repair
  • Polylactic acid

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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