Effectiveness of a multi-disciplinary standardized management model in the treatment of chronic hepatitis C in drug addicts engaged in detoxification programmes

Vincenzo Guadagnino, Maria Paola Trotta, Franco Montesano, Sergio Babudieri, Benedetto Caroleo, Orlando Armignacco, Jessica Carioti, Giuseppe Maio, Roberto Monarca, Andrea Antinori

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Abstract

Aim: To evaluate the effect of a multi-disciplinary standardized management model on the efficacy of pegylated (Peg)-interferon α-2b plus ribavirin treatment of chronic hepatitis C in drug addicts undergoing substitutive or antagonist therapy. Design: Observational prospective multi-centre study. Setting: Six clinical infectious disease centres in collaboration with 11 drug dependency units (DDU) in five Italian regions. Participants: Intravenous drug users affected by chronic hepatitis C engaged in detoxification programmes. Methods: Application of a multi-disciplinary standardized management model for HCV treatment involving DDU operators, psychologists or psychiatrists and infectious disease specialists. Measurements: Very early, early, end-of-treatment and sustained virological response to Peg-interferon α-2b plus ribavirin. Findings: Fifty-three subjects were studied [43.4% with hepatitis C virus (HCV) genotypes 1 or 4]. Intent-to-treat analysis showed an end-of-treatment virological response in 58.5% of patients (39.1% genotypes 1 or 4; 73.4% genotype 3) and a sustained virological response in 54.7% (34.8% genotypes 1 or 4; 70.0% genotype 3). There were 19 (35.8%) dropouts and three (5.7%) non-responders: one genotype 1 and two genotype 4. Two (3.8%) patients relapsed: genotypes 1 and 3. On-treatment analysis showed negative HCV-RNA in 40 (93.1%) of 43 subjects who completed the first 12 treatment weeks and in 35 who completed the first 24 treatment weeks. All subjects with an end-of-treatment response, except one with genotype 3 infection, had a sustained response. Conclusions: Our data show that antiviral treatment in the context of a multi-disciplinary standardized management model helps many HCV-positive drug addicts achieve a good virological response.

Original languageEnglish
Pages (from-to)423-431
Number of pages9
JournalAddiction
Volume102
Issue number3
DOIs
Publication statusPublished - Mar 2007

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Keywords

  • HCV infection
  • Intravenous drug use
  • Management of hepatitis C
  • Peg interferon

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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