Effectiveness of a rehabilitative programme in improving fatigue and function in rheumatoid arthritis patients treated with biologics: A pilot study

Luisa Di Gioia, Carmela Zincarelli, Matteo Nicola Dario Di Minno, Giuseppe Rengo, Rosario Peluso, Angelo Spanò, Salvatore Iervolino, Nicola Pappone

Research output: Contribution to journalArticle

Abstract

Objective. To evaluate the effectiveness of a personalised rehabilitative programme in improving fatigue and function in rheumatoid arthritis (RA) female patients treated with biologic DMARDs. Methods. Thirty-eight consecutive female RA in-patients treated with biologics, entered this prospective pilot study. All subjects were in high disease activity (DAS-28>5.1). After baseline (T0) evaluation, a personalised 4-weeks rehabilitative programme was added to standard biologic treatment and all patients were re-evaluated at the end of the rehabilitative treatment (T1), at 3 (T2), 6 (T3) and 9 (T4) month followup. Clinical rheumatologic assessment included the DAS-28, TJC, SJC, global health status, HAQ and FACIT. Results. Subjects showed a mean age of 65±3.5 years and a 10±1,1 years mean disease duration. All clinical and laboratory outcomes significantly improved at the different follow-up times as compared to baseline. In particular, a significant improvement in function and fatigue indices (HAQ and FACIT) was found since T1 to T4 as compared to T0. During the follow-up, DAS-28 decreased. Accordingly, about 30% of subjects achieved a moderate disease activity (DAS-28

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalClinical and Experimental Rheumatology
Volume31
Issue number2
Publication statusPublished - 2013

Keywords

  • Fatigue
  • Functional class
  • Rehabilitation
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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