Effectiveness of adalimumab for the treatment of psoriatic arthritis: An Italian real-life retrospective study

Salvatore D'Angelo, Fabrizio Cantini, Roberta Ramonda, Luca Cantarini, Antonio Carletto, Maria Sole Chimenti, Andrea Delle Sedie, Rosario Foti, Roberto Gerli, Claudia Lomater, Ennio Lubrano, Antonio Marchesoni, Alen Zabotti, Carlo Salvarani, Rossana Scrivo, Raffaele Scarpa, Giuseppina Tramontano, Carlotta Nannini, Mariagrazia Lorenzin, Marta FabbroniFederica Martinis, Roberto Perricone, Linda Carli, Elisa Visalli, Guido Rovera, Fabio Massimo Perrotta, Luca Quartuccio, Alessio Altobelli, Luisa Costa, Laura Niccoli, Augusta Ortolan, Francesco Caso

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Few studies have evaluated the effectiveness of adalimumab in the real-life setting in psoriatic arthritis (PsA). Objective: To evaluate the 2-year retention rate of adalimumab in PsA patients. Potential baseline parameters influencing persistence on treatment were also evaluated. Methods: PsA patients from 16 Italian Rheumatology Units treated with adalimumab as first- or second-line biological therapy were retrospectively evaluated. Adalimumab retention rate was evaluated at 12 and 24 months. Logistic regression was used to evaluate the association between predictor variables and adalimumab retention rate. Results: From 424 patients (53.5% male, aged 48.3 ± 12.8 years) who started treatment with adalimumab, 367 (86.6%) maintained treatment for 12 months and 313 (73.8%) for 2 years. At 24-months, Disease Activity in PsA (DAPSA) remission (defined as ≤4) and Low Disease Activity (LDA) (≤14) were achieved in 22.8% and 44.4% of patients, respectively. Adalimumab treatment significantly decreased the number of tender (7.0 ± 5.7 at baseline vs. 2.3 ± 3.5 at 24 months, p < 0.001) and swollen joints (2.7 ± 2.8 at baseline vs. 0.4 ± 0.9 at 24 months, p < 0.001), DAPSA (25.5 ± 10.9 at baseline vs. 11.0 ± 8.4 at 24 months, p < 0.001), PASI (5.3 ± 5.7 at baseline vs. 2.7 ± 2.8 at 24 months, p < 0.001) and CRP (3.8 ± 6.3 at baseline vs. 1.2 ± 1.7 at 24 months, p < 0.001). Among a range of laboratory and clinical variables, only female gender was associated with improved adalimumab persistence at 24 months (OR: 1.98, 95% CI: 1.2-3.2, p = 0.005). Conclusions: Independent of a range of predictor variables, adalimumab was shown to be effective, while maintaining a high retention rate after 2 years in PsA patients.

Original languageEnglish
Article number1497
JournalFrontiers in Pharmacology
Volume10
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Adalimumab
  • Biological drugs
  • Psoriatic arthritis
  • Real-life
  • Retention rate

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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