Effectiveness of autocrosslinked hyaluronic acid gel after laparoscopic myomectomy in infertile patients: A prospective, randomized, controlled study

Massimiliano Pellicano, Silvia Bramante, Domenico Cirillo, Stefano Palomba, Giuseppe Bifulco, Fulvio Zullo, Carmine Nappi

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Objective: To assess the efficacy of autocrosslinked hyaluronic gel in postsurgical adhesion prevention after laparoscopic myomectomy. Design: Prospective, randomized, controlled study. Setting: University of Naples "Federico II". Patient(s): Thirty-six infertile women with symptomatic myomas were randomly divided into two groups of 18 patients each. Intervention(s): Laparoscopic myomectomy with subserous sutures or interrupted figure 8 sutures, with (group A) or without (group B) application of autocrosslinked hyaluronic acid (HA) gel. Main Outcome Measure(s): Rate of postsurgical adhesions at 60-90 days of follow-up. Result(s): The rate of subjects who developed postoperative adhesions was significantly lower in group A in comparison with group B (27.8% vs. 77.8%). In both groups, the rate of adhesions was significantly higher in patients treated with interrupted figure 8 sutures than with subserous sutures. Conclusion(s): Autocrosslinked HA gel is a promising resorbable agent barrier for the reduction of postoperative adhesions after laparoscopic myomectomy. Moreover, the type of suture is a factor influencing the postsurgical adhesion formation.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalFertility and Sterility
Volume80
Issue number2
DOIs
Publication statusPublished - Aug 1 2003

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Uterine Myomectomy
Hyaluronic Acid
Sutures
Gels
Myoma
Outcome Assessment (Health Care)

Keywords

  • Adhesions
  • Autocrosslinked hyaluronic acid gel
  • Infertile patients
  • Laparoscopic myomectomy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Effectiveness of autocrosslinked hyaluronic acid gel after laparoscopic myomectomy in infertile patients : A prospective, randomized, controlled study. / Pellicano, Massimiliano; Bramante, Silvia; Cirillo, Domenico; Palomba, Stefano; Bifulco, Giuseppe; Zullo, Fulvio; Nappi, Carmine.

In: Fertility and Sterility, Vol. 80, No. 2, 01.08.2003, p. 441-444.

Research output: Contribution to journalArticle

Pellicano, Massimiliano ; Bramante, Silvia ; Cirillo, Domenico ; Palomba, Stefano ; Bifulco, Giuseppe ; Zullo, Fulvio ; Nappi, Carmine. / Effectiveness of autocrosslinked hyaluronic acid gel after laparoscopic myomectomy in infertile patients : A prospective, randomized, controlled study. In: Fertility and Sterility. 2003 ; Vol. 80, No. 2. pp. 441-444.
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