Abstract
Structural and functional abnormalities of the cerebellum have been observed in schizophrenia since the first neuroimaging studies. More recently, the functions of the cerebellum have been extended beyond sensorimotor control to include participation in higher-level cognition and affective regulation. Consistently, the "cognitive dysmetria" theory posits that dysfunctions of cortical-subcortical-cerebellar circuitry may be crucial for the pathogenesis of different clinical features of schizophrenia. This conceptual framework offers a set of testable hypotheses, now that various tools to exert direct modulation of cerebellar activity are available. We conducted a systematic review of studies examining the effects of cerebellar modulation in schizophrenia. Two independent authors conducted a search within PubMed for articles published up to April 2019 and identified 10 studies (three randomized controlled trials, two open-label studies, two case reports, one preclinical study) describing the effects of cerebellar circuitry modulation in patients with schizophrenia or animal models. The majority of interventions were uncontrolled and used stimulation of the cerebellar vermis, using transcranial magnetic stimulation or transcranial direct-current stimulation. Most studies detected improvements after cerebellar modulation. Clinical changes mostly pertained the domains of negative symptoms, depressive symptoms and cognitive functions. In conclusion, few studies examined the effects of cerebellar modulation in schizophrenia but yielded promising results. This approach may hold therapeutic potential, pending further methodologically robust replication.
| Original language | English |
|---|---|
| Pages (from-to) | 977-986 |
| Number of pages | 10 |
| Journal | The Journal of nervous and mental disease |
| Volume | 207 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2019 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Effectiveness of Cerebellar Circuitry Modulation in Schizophrenia : A Systematic Review. / Escelsior, Andrea; Belvederi Murri, Martino; Calcagno, Pietro; Cervetti, Alice; Caruso, Rosangela; Croce, Enrico; Grassi, Luigi; Amore, Mario.
In: The Journal of nervous and mental disease, Vol. 207, No. 11, 01.11.2019, p. 977-986.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effectiveness of Cerebellar Circuitry Modulation in Schizophrenia
T2 - A Systematic Review
AU - Escelsior, Andrea
AU - Belvederi Murri, Martino
AU - Calcagno, Pietro
AU - Cervetti, Alice
AU - Caruso, Rosangela
AU - Croce, Enrico
AU - Grassi, Luigi
AU - Amore, Mario
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Structural and functional abnormalities of the cerebellum have been observed in schizophrenia since the first neuroimaging studies. More recently, the functions of the cerebellum have been extended beyond sensorimotor control to include participation in higher-level cognition and affective regulation. Consistently, the "cognitive dysmetria" theory posits that dysfunctions of cortical-subcortical-cerebellar circuitry may be crucial for the pathogenesis of different clinical features of schizophrenia. This conceptual framework offers a set of testable hypotheses, now that various tools to exert direct modulation of cerebellar activity are available. We conducted a systematic review of studies examining the effects of cerebellar modulation in schizophrenia. Two independent authors conducted a search within PubMed for articles published up to April 2019 and identified 10 studies (three randomized controlled trials, two open-label studies, two case reports, one preclinical study) describing the effects of cerebellar circuitry modulation in patients with schizophrenia or animal models. The majority of interventions were uncontrolled and used stimulation of the cerebellar vermis, using transcranial magnetic stimulation or transcranial direct-current stimulation. Most studies detected improvements after cerebellar modulation. Clinical changes mostly pertained the domains of negative symptoms, depressive symptoms and cognitive functions. In conclusion, few studies examined the effects of cerebellar modulation in schizophrenia but yielded promising results. This approach may hold therapeutic potential, pending further methodologically robust replication.
AB - Structural and functional abnormalities of the cerebellum have been observed in schizophrenia since the first neuroimaging studies. More recently, the functions of the cerebellum have been extended beyond sensorimotor control to include participation in higher-level cognition and affective regulation. Consistently, the "cognitive dysmetria" theory posits that dysfunctions of cortical-subcortical-cerebellar circuitry may be crucial for the pathogenesis of different clinical features of schizophrenia. This conceptual framework offers a set of testable hypotheses, now that various tools to exert direct modulation of cerebellar activity are available. We conducted a systematic review of studies examining the effects of cerebellar modulation in schizophrenia. Two independent authors conducted a search within PubMed for articles published up to April 2019 and identified 10 studies (three randomized controlled trials, two open-label studies, two case reports, one preclinical study) describing the effects of cerebellar circuitry modulation in patients with schizophrenia or animal models. The majority of interventions were uncontrolled and used stimulation of the cerebellar vermis, using transcranial magnetic stimulation or transcranial direct-current stimulation. Most studies detected improvements after cerebellar modulation. Clinical changes mostly pertained the domains of negative symptoms, depressive symptoms and cognitive functions. In conclusion, few studies examined the effects of cerebellar modulation in schizophrenia but yielded promising results. This approach may hold therapeutic potential, pending further methodologically robust replication.
UR - http://www.scopus.com/inward/record.url?scp=85074305164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074305164&partnerID=8YFLogxK
U2 - 10.1097/NMD.0000000000001064
DO - 10.1097/NMD.0000000000001064
M3 - Article
C2 - 31503187
AN - SCOPUS:85074305164
VL - 207
SP - 977
EP - 986
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
SN - 0022-3018
IS - 11
ER -