Effectiveness of differentiation inducers in combination on human neuroblastoma cells in vitro

P. Rocchi, G. Simone, A. Lorenzetti, D. Granchi, P. Paolucci, G. Paolucci

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effects of epirubicin and retinoic acid (RA) as differentiation inducing agents on human neuroblastoma cell lines were investigated. We have compared the response of neuroblastoma cells to epirubicin alone, to RA alone and to combined treatment, with respect to neuritic processes out-growth, acetylcholinesterase activity, growth inhibition and antigenic expression. The obtained data indicate that the combination of the two agents is able to produce a synergistic effect on differentiation and on growth inhibition.

Original languageEnglish
Pages (from-to)1605-1610
Number of pages6
JournalAnticancer Research
Volume9
Issue number6
Publication statusPublished - 1989

Fingerprint

Neuroblastoma
Epirubicin
Tretinoin
Growth
Acetylcholinesterase
Cell Line
In Vitro Techniques

Keywords

  • differentiation
  • epirubicin
  • neuroblastoma
  • retinoic acid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Rocchi, P., Simone, G., Lorenzetti, A., Granchi, D., Paolucci, P., & Paolucci, G. (1989). Effectiveness of differentiation inducers in combination on human neuroblastoma cells in vitro. Anticancer Research, 9(6), 1605-1610.

Effectiveness of differentiation inducers in combination on human neuroblastoma cells in vitro. / Rocchi, P.; Simone, G.; Lorenzetti, A.; Granchi, D.; Paolucci, P.; Paolucci, G.

In: Anticancer Research, Vol. 9, No. 6, 1989, p. 1605-1610.

Research output: Contribution to journalArticle

Rocchi, P, Simone, G, Lorenzetti, A, Granchi, D, Paolucci, P & Paolucci, G 1989, 'Effectiveness of differentiation inducers in combination on human neuroblastoma cells in vitro', Anticancer Research, vol. 9, no. 6, pp. 1605-1610.
Rocchi, P. ; Simone, G. ; Lorenzetti, A. ; Granchi, D. ; Paolucci, P. ; Paolucci, G. / Effectiveness of differentiation inducers in combination on human neuroblastoma cells in vitro. In: Anticancer Research. 1989 ; Vol. 9, No. 6. pp. 1605-1610.
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