Effectiveness of differentiation inducers in combination on human neuroblastoma cells in vitro

P. Rocchi, G. Simone, A. Lorenzetti, D. Granchi, P. Paolucci, G. Paolucci

Research output: Contribution to journalArticle

Abstract

The effects of epirubicin and retinoic acid (RA) as differentiation inducing agents on human neuroblastoma cell lines were investigated. We have compared the response of neuroblastoma cells to epirubicin alone, to RA alone and to combined treatment, with respect to neuritic processes out-growth, acetylcholinesterase activity, growth inhibition and antigenic expression. The obtained data indicate that the combination of the two agents is able to produce a synergistic effect on differentiation and on growth inhibition.

Original languageEnglish
Pages (from-to)1605-1610
Number of pages6
JournalAnticancer Research
Volume9
Issue number6
Publication statusPublished - 1989

Keywords

  • differentiation
  • epirubicin
  • neuroblastoma
  • retinoic acid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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