Effectiveness of ibuprofen-arginine in the treatment of acute migraine attacks

G. Sandrini, S. Franchini, S. Lanfranchi, F. Granella, G. C. Manzoni, G. Nappi

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to evaluate the effectiveness of a new formulation of ibuprofen (ibuprofen-arginine [IA]) in the treatment of migraine attacks. This is a faster absorbed formulation as compared with ibuprofen alone. The rapidity of action is considered to be a crucial factor in the treatment of migraine attacks. Forty migraine patients participated in this multicenter, double-blind, crossover, randomized, placebo-controlled trial. Each patient was treated with a single oral dose of IA 400 mg or placebo during two consecutive migraine attacks. The results confirm the efficacy of IA, with a significant (p <0.05) improvement in pain relief at 30 min after treatment. A statistically significant (p <0.001) reduction in pain intensity was observed at 1, 2, 4 and 6 h after treatment with ibuprofen as compared with placebo. IA was well tolerated and our data indicate that this new formulation of ibuprofen is valuable in the treatment of acute migraine attacks.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalInternational Journal of Clinical Pharmacology Research
Volume18
Issue number3
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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