Effectiveness of immunoglobulin replacement therapy on clinical outcome in patients with primary antibody deficiencies: Results from a multicenter prospective cohort study

Isabella Quinti, Annarosa Soresina, Andrea Guerra, Roberto Rondelli, Giuseppe Spadaro, Carlo Agostini, Cinzia Milito, Amelia Chiara Trombetta, Marcella Visentini, Helene Martini, Alessandro Plebani, Massimo Fiorilli, D. De Mattia, B. Martire, F. Cardinale, G. Ranieri, F. Silvestri, M. Masi, A. Pession, F. CossuE. Anastasio, G. Schillirò, A. Matucci, A. Vultaggio, M. Aricò, M. C. Pietrogrande, R. M. Delle Piane, C. Panisi, G. Cambiaghi, C. Pignata, M. C. Putti, A. Trizzino, P. Bertolini, R. Consolini, A. G. Ugazio, M. Duse, M. Iacobini, V. Moschese, C. Cancrini, A. Finocchi, A. M. Pesce, M. Cagliuso, V. Conti, G. Granata, M. Mitrevski, F. Cecere, P. A. Tovo, S. Martino, D. Montin, L. Nespoli, M. Marinoni, F. P. Pellegrini, G. A. Cazzola

Research output: Contribution to journalArticlepeer-review

Abstract

A 5-years multicenter prospective study on 201 patients with common variable immunodeficiencies and 101 patients with X-linked agammaglobulinemia over a cumulative follow-up period of 1,365 patient-years was conducted to identify prognostic markers and risk factors for associated clinical co-morbidities, the effects of long-term immunoglobulin treatment and the IgG trough level to be maintained over time required to minimise infection risk. Overall, 21% of the patients with common variable immunodeficiencies and 24% of patients with X-linked agammaglobulinemia remained infection free during the study. A reduction of pneumonia episodes has been observed after initiation of Ig replacement. During the observation time, pneumonia incidence remained low and constant over time. Patients with pneumonia did not have significant lower IgG trough levels than patients without pneumonia, with the exception of patients whose IgG trough levels were persistently

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalJournal of Clinical Immunology
Volume31
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • bronchiectasis
  • common variable immunodeficiency
  • effectiveness
  • IgA
  • Immunoglobulin replacement
  • X-linked agammaglobulinemia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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