Effectiveness of individualized lung recruitment strategies at birth

An experimental study in preterm lambs

David G. Tingay, Anushi Rajapaksa, Emanuela Zannin, Prue M. Pereira-Fantini, Raffaele L. Dellaca, Elizabeth J. Perkins, Cornelis E.E. Zonneveld, Andy Adler, Don Black, Inéz Frerichs, Anna Lavizzari, Magdy Sourial, Bartłomiej Grychtol, Fabio Mosca, Peter G. Davis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Respiratory transition at birth involves rapidly clearing fetal lung liquid and preventing efflux back into the lung while aeration is established. We have developed a sustained inflation (SIOPT) individualized to volume response and a dynamic tidal positive end-expiratory pressure (PEEP) (open lung volume, OLV) strategy that both enhance this process. We aimed to compare the effect of each with a group managed with PEEP of 8 cmH2O and no recruitment maneuver (No-RM), on gas exchange, lung mechanics, spatiotemporal aeration, and lung injury in 127 ± 1 day preterm lambs. Forty-eight fetal-instrumented lambs exposed to antenatal steroids were ventilated for 60 min after application of the allocated strategy. Spatiotemporal aeration and lung mechanics were measured with electrical impedance tomography and forced-oscillation, respectively. At study completion, molecular and histological markers of lung injury were analyzed. Mean (SD) aeration at the end of the SIOPT and OLV groups was 32 (22) and 38 (15) ml/kg, compared with 17 (10) ml/kg (180 s) in the No-RM (P = 0.024, 1-way ANOVA). This translated into better oxygenation at 60 min (P = 0.047; 2-way ANOVA) resulting from better distal lung tissue aeration in SIOPT and OLV. There was no difference in lung injury. Neither SIOPT nor OLV achieved homogeneous aeration. Histological injury and mRNA biomarker upregulation were more likely in the regions with better initial aeration, suggesting volutrauma. Tidal ventilation or an SI achieves similar aeration if optimized, suggesting that preventing fluid efflux after lung liquid clearance is at least as important as fluid clearance during the initial inflation at birth.

Original languageEnglish
Pages (from-to)L32-L41
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume312
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

Parturition
Lung
Lung Injury
Positive-Pressure Respiration
Economic Inflation
Mechanics
Analysis of Variance
Electric Impedance
Ventilation
Up-Regulation
Biomarkers
Gases
Steroids
Tomography
Messenger RNA
Wounds and Injuries

Keywords

  • Infant
  • Lung mechanics
  • Open lung ventilation
  • Preterm
  • Regional lung injury
  • Sustained inflation

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Cell Biology
  • Physiology (medical)

Cite this

Effectiveness of individualized lung recruitment strategies at birth : An experimental study in preterm lambs. / Tingay, David G.; Rajapaksa, Anushi; Zannin, Emanuela; Pereira-Fantini, Prue M.; Dellaca, Raffaele L.; Perkins, Elizabeth J.; Zonneveld, Cornelis E.E.; Adler, Andy; Black, Don; Frerichs, Inéz; Lavizzari, Anna; Sourial, Magdy; Grychtol, Bartłomiej; Mosca, Fabio; Davis, Peter G.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 312, No. 1, 2017, p. L32-L41.

Research output: Contribution to journalArticle

Tingay, DG, Rajapaksa, A, Zannin, E, Pereira-Fantini, PM, Dellaca, RL, Perkins, EJ, Zonneveld, CEE, Adler, A, Black, D, Frerichs, I, Lavizzari, A, Sourial, M, Grychtol, B, Mosca, F & Davis, PG 2017, 'Effectiveness of individualized lung recruitment strategies at birth: An experimental study in preterm lambs', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 312, no. 1, pp. L32-L41. https://doi.org/10.1152/ajplung.00416.2016
Tingay, David G. ; Rajapaksa, Anushi ; Zannin, Emanuela ; Pereira-Fantini, Prue M. ; Dellaca, Raffaele L. ; Perkins, Elizabeth J. ; Zonneveld, Cornelis E.E. ; Adler, Andy ; Black, Don ; Frerichs, Inéz ; Lavizzari, Anna ; Sourial, Magdy ; Grychtol, Bartłomiej ; Mosca, Fabio ; Davis, Peter G. / Effectiveness of individualized lung recruitment strategies at birth : An experimental study in preterm lambs. In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 2017 ; Vol. 312, No. 1. pp. L32-L41.
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