Efficacia della somministrazione di Lamotrigina a lungo termine in soggetti con epilessia farmacoresistente

Translated title of the contribution: Effectiveness of long-term lamotrigine treatment in drug-resistant epilepsy

S. A. Musumeci, M. Elia, A. Castano, R. Ferri, S. Del Gracco, M. C. Stefanini

Research output: Contribution to journalArticle

Abstract

Eight female patients (age range 10-36 years) affected by symptomatic drug-resistant epilepsy were included in an add-on therapeutic trial with lamotrigine (200-350 mg/day). In all subjects, seizure frequency was evaluated during the two months preceding the administration of lamotrigine and during the 12 months of therapy, subdivided into 4-month periods. Furthermore, EEG during wakefulness and sleep polygraphic recordings were obtained just before the start of the treatment with lamotrigine and 3 and 12 months after. These allowed us to quantify both the interictal paroxysmal EEG activity and the ictal paroxysmal episodes. The results, showing a significant decrease of both clinical and laboratory indexes of paroxysmal activity, which became evident after the first 4 months of therapy and was maintained during the whole period of study, allow us to confirm the long- term effectiveness of lamotrigine in the treatment of drug-resistant epilepsy.

Translated title of the contributionEffectiveness of long-term lamotrigine treatment in drug-resistant epilepsy
Original languageItalian
Pages (from-to)241-242
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number95-96
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Clinical Neurology

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