Abstract
Eight female patients (age range 10-36 years) affected by symptomatic drug-resistant epilepsy were included in an add-on therapeutic trial with lamotrigine (200-350 mg/day). In all subjects, seizure frequency was evaluated during the two months preceding the administration of lamotrigine and during the 12 months of therapy, subdivided into 4-month periods. Furthermore, EEG during wakefulness and sleep polygraphic recordings were obtained just before the start of the treatment with lamotrigine and 3 and 12 months after. These allowed us to quantify both the interictal paroxysmal EEG activity and the ictal paroxysmal episodes. The results, showing a significant decrease of both clinical and laboratory indexes of paroxysmal activity, which became evident after the first 4 months of therapy and was maintained during the whole period of study, allow us to confirm the long- term effectiveness of lamotrigine in the treatment of drug-resistant epilepsy.
| Original language | Italian |
|---|---|
| Pages (from-to) | 241-242 |
| Number of pages | 2 |
| Journal | Bollettino - Lega Italiana contro l'Epilessia |
| Issue number | 95-96 |
| Publication status | Published - 1996 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Efficacia della somministrazione di Lamotrigina a lungo termine in soggetti con epilessia farmacoresistente. / Musumeci, S. A.; Elia, M.; Castano, A.; Ferri, R.; Del Gracco, S.; Stefanini, M. C.
In: Bollettino - Lega Italiana contro l'Epilessia, No. 95-96, 1996, p. 241-242.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacia della somministrazione di Lamotrigina a lungo termine in soggetti con epilessia farmacoresistente
AU - Musumeci, S. A.
AU - Elia, M.
AU - Castano, A.
AU - Ferri, R.
AU - Del Gracco, S.
AU - Stefanini, M. C.
PY - 1996
Y1 - 1996
N2 - Eight female patients (age range 10-36 years) affected by symptomatic drug-resistant epilepsy were included in an add-on therapeutic trial with lamotrigine (200-350 mg/day). In all subjects, seizure frequency was evaluated during the two months preceding the administration of lamotrigine and during the 12 months of therapy, subdivided into 4-month periods. Furthermore, EEG during wakefulness and sleep polygraphic recordings were obtained just before the start of the treatment with lamotrigine and 3 and 12 months after. These allowed us to quantify both the interictal paroxysmal EEG activity and the ictal paroxysmal episodes. The results, showing a significant decrease of both clinical and laboratory indexes of paroxysmal activity, which became evident after the first 4 months of therapy and was maintained during the whole period of study, allow us to confirm the long- term effectiveness of lamotrigine in the treatment of drug-resistant epilepsy.
AB - Eight female patients (age range 10-36 years) affected by symptomatic drug-resistant epilepsy were included in an add-on therapeutic trial with lamotrigine (200-350 mg/day). In all subjects, seizure frequency was evaluated during the two months preceding the administration of lamotrigine and during the 12 months of therapy, subdivided into 4-month periods. Furthermore, EEG during wakefulness and sleep polygraphic recordings were obtained just before the start of the treatment with lamotrigine and 3 and 12 months after. These allowed us to quantify both the interictal paroxysmal EEG activity and the ictal paroxysmal episodes. The results, showing a significant decrease of both clinical and laboratory indexes of paroxysmal activity, which became evident after the first 4 months of therapy and was maintained during the whole period of study, allow us to confirm the long- term effectiveness of lamotrigine in the treatment of drug-resistant epilepsy.
KW - Drug-resistant epilepsy
KW - Lamotrigine
UR - http://www.scopus.com/inward/record.url?scp=0030417105&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030417105&partnerID=8YFLogxK
M3 - Articolo
SP - 241
EP - 242
JO - Bollettino - Lega Italiana contro l'Epilessia
JF - Bollettino - Lega Italiana contro l'Epilessia
SN - 0394-560X
IS - 95-96
ER -