EFFECTIVENESS OF LOW-DOSE HEPARIN IN PREVENTION OF MYOCARDIAL REINFARCTION

G. G. Neri Serneri, G. F. Gensini, M. Carnovali, F. Rovelli, S. Pirelli, A. Fortini

Research output: Contribution to journalArticle

Abstract

728 patients aged 50-75 years who had had Q-wave myocardial infarction 6-18 months previously were enrolled in a randomised, multicentre trial of low-dose heparin in prevention of reinfarction. The control group (365 patients) received their study centres' usual therapy; the heparin group (363 patients) also received subcutaneous calcium heparin (12 500 IU daily). Mean (SD) follow-up was 708 (265) days in the heparin group and 687 (251) in the control group. The reinfarction rate was 63% lower in the heparin than in the control group (4/303, 1·32% υ 13/365, 3·56%). The difference in cumulative reinfarction rate between the groups was significant by both drug-efficacy (χ2=3·99, p2=3·84, p=0·05). Heparin treatment reduced the cumulative general mortality rates by 48% on drug-efficacy analysis (χ2=3·88, p2=2·05, not significant). Cardiovascular mortality was also reduced (33%) but not significantly. However, fatal events attributable to thromboembolism (fatal reinfarction, stroke, pulmonary embolism) were significantly less frequent in the heparin than in the control group (1 υ 7, p

Original languageEnglish
Pages (from-to)937-942
Number of pages6
JournalLancet
Volume329
Issue number8539
DOIs
Publication statusPublished - Apr 25 1987

ASJC Scopus subject areas

  • Medicine(all)

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