Effectiveness of Madopar HBS plus Madopar standard in patients with fluctuating Parkinson's disease: Two years of follow-up

C. Pacchetti, E. Martignoni, L. Sibilla, P. Bruggi, M. Turla, G. Nappi

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical response to a new galenic formulation of levodopa plus benserazide, Madopar HBS, was studied in 25 fluctuating parkinsonians. This open study was planned in two phases. In the first phase, the administering of HBS alone resulted in a surprisingly high number of dropouts. In the second phase, Madopar standard in association with Madopar HBS, the follow-up period was 24 months. A stable long-lasting improvement in predictable fluctuations and their severity was maintained for the whole period without any change in drug dose. Nocturnal and early morning akinesia improved too. The study shows that Madopar HBS plus Madopar standard is effective in producing a prolonged and stable response in parkinsonian fluctuating patients.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalEuropean Neurology
Volume30
Issue number6
Publication statusPublished - 1990

Keywords

  • long-term study
  • Madopar HBS
  • motor fluctuations
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology

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