Effectiveness of neoadjuvant radiotherapy in the treatment of locally advanced rectal cancer

A single-center experience in 263 patients

Giovanni Bisceglia, Nicola Mastrodonato, Beniamino Rucci, Pietro Corsa, Salvatore Parisi, Berardino Tardio, P. Di Sebastiano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: To determine the frequency of local recurrence (LR) and distant recurrence (DR) with 5-year survival analysis. Methods: Patients with T3-T4 rectal cancer located within 10 cm from the anal verge. Radiotherapy protocol: 36 Gy, delivered in 12 daily doses of 3 Gy each for 5 days/week, followed by surgery after a 2-week break. Results: 263 patients were recruited. Radiotherapy was well tolerated. None of the patients broke off treatment. Complete histological response was 3% and maximum radio-induced downstaging 31.4%. Overall complication rate was 25.8% and direct radio-induced complications 0.4%. Mean duration of treatment was 35.7 days. In 172 patients with a minimum follow-up of 5 years, the rate of LR was 6.0% and DR 24.4%. Five-year overall survival was 70.2%, overall specific survival 78.0%, disease-free survival 70.7%, LR-free specific survival 92.9%, and DR-free specific survival 73.5%. Conclusions: In our experience, local disease control was achieved in 94% of patients. Any changes in our treatment protocols will aim at improving results in terms of LR and DR. In view of the four-fold higher rate of DR as compared to LR, improvement of DR can be defined as the challenge for the future.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalDigestive Surgery
Volume27
Issue number3
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Rectal Neoplasms
Radiotherapy
Recurrence
Therapeutics
Survival
Radio
Survival Analysis
Clinical Protocols
Disease-Free Survival

Keywords

  • Locally advanced rectal cancer
  • Neoadjuvant radiotherapy
  • Total mesorectal excision

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Bisceglia, G., Mastrodonato, N., Rucci, B., Corsa, P., Parisi, S., Tardio, B., & Di Sebastiano, P. (2010). Effectiveness of neoadjuvant radiotherapy in the treatment of locally advanced rectal cancer: A single-center experience in 263 patients. Digestive Surgery, 27(3), 217-223. https://doi.org/10.1159/000274459

Effectiveness of neoadjuvant radiotherapy in the treatment of locally advanced rectal cancer : A single-center experience in 263 patients. / Bisceglia, Giovanni; Mastrodonato, Nicola; Rucci, Beniamino; Corsa, Pietro; Parisi, Salvatore; Tardio, Berardino; Di Sebastiano, P.

In: Digestive Surgery, Vol. 27, No. 3, 08.2010, p. 217-223.

Research output: Contribution to journalArticle

Bisceglia, G, Mastrodonato, N, Rucci, B, Corsa, P, Parisi, S, Tardio, B & Di Sebastiano, P 2010, 'Effectiveness of neoadjuvant radiotherapy in the treatment of locally advanced rectal cancer: A single-center experience in 263 patients', Digestive Surgery, vol. 27, no. 3, pp. 217-223. https://doi.org/10.1159/000274459
Bisceglia, Giovanni ; Mastrodonato, Nicola ; Rucci, Beniamino ; Corsa, Pietro ; Parisi, Salvatore ; Tardio, Berardino ; Di Sebastiano, P. / Effectiveness of neoadjuvant radiotherapy in the treatment of locally advanced rectal cancer : A single-center experience in 263 patients. In: Digestive Surgery. 2010 ; Vol. 27, No. 3. pp. 217-223.
@article{9627a817b2e341fab30982b481fa8e37,
title = "Effectiveness of neoadjuvant radiotherapy in the treatment of locally advanced rectal cancer: A single-center experience in 263 patients",
abstract = "Aim: To determine the frequency of local recurrence (LR) and distant recurrence (DR) with 5-year survival analysis. Methods: Patients with T3-T4 rectal cancer located within 10 cm from the anal verge. Radiotherapy protocol: 36 Gy, delivered in 12 daily doses of 3 Gy each for 5 days/week, followed by surgery after a 2-week break. Results: 263 patients were recruited. Radiotherapy was well tolerated. None of the patients broke off treatment. Complete histological response was 3{\%} and maximum radio-induced downstaging 31.4{\%}. Overall complication rate was 25.8{\%} and direct radio-induced complications 0.4{\%}. Mean duration of treatment was 35.7 days. In 172 patients with a minimum follow-up of 5 years, the rate of LR was 6.0{\%} and DR 24.4{\%}. Five-year overall survival was 70.2{\%}, overall specific survival 78.0{\%}, disease-free survival 70.7{\%}, LR-free specific survival 92.9{\%}, and DR-free specific survival 73.5{\%}. Conclusions: In our experience, local disease control was achieved in 94{\%} of patients. Any changes in our treatment protocols will aim at improving results in terms of LR and DR. In view of the four-fold higher rate of DR as compared to LR, improvement of DR can be defined as the challenge for the future.",
keywords = "Locally advanced rectal cancer, Neoadjuvant radiotherapy, Total mesorectal excision",
author = "Giovanni Bisceglia and Nicola Mastrodonato and Beniamino Rucci and Pietro Corsa and Salvatore Parisi and Berardino Tardio and {Di Sebastiano}, P.",
year = "2010",
month = "8",
doi = "10.1159/000274459",
language = "English",
volume = "27",
pages = "217--223",
journal = "Digestive Surgery",
issn = "0253-4886",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Effectiveness of neoadjuvant radiotherapy in the treatment of locally advanced rectal cancer

T2 - A single-center experience in 263 patients

AU - Bisceglia, Giovanni

AU - Mastrodonato, Nicola

AU - Rucci, Beniamino

AU - Corsa, Pietro

AU - Parisi, Salvatore

AU - Tardio, Berardino

AU - Di Sebastiano, P.

PY - 2010/8

Y1 - 2010/8

N2 - Aim: To determine the frequency of local recurrence (LR) and distant recurrence (DR) with 5-year survival analysis. Methods: Patients with T3-T4 rectal cancer located within 10 cm from the anal verge. Radiotherapy protocol: 36 Gy, delivered in 12 daily doses of 3 Gy each for 5 days/week, followed by surgery after a 2-week break. Results: 263 patients were recruited. Radiotherapy was well tolerated. None of the patients broke off treatment. Complete histological response was 3% and maximum radio-induced downstaging 31.4%. Overall complication rate was 25.8% and direct radio-induced complications 0.4%. Mean duration of treatment was 35.7 days. In 172 patients with a minimum follow-up of 5 years, the rate of LR was 6.0% and DR 24.4%. Five-year overall survival was 70.2%, overall specific survival 78.0%, disease-free survival 70.7%, LR-free specific survival 92.9%, and DR-free specific survival 73.5%. Conclusions: In our experience, local disease control was achieved in 94% of patients. Any changes in our treatment protocols will aim at improving results in terms of LR and DR. In view of the four-fold higher rate of DR as compared to LR, improvement of DR can be defined as the challenge for the future.

AB - Aim: To determine the frequency of local recurrence (LR) and distant recurrence (DR) with 5-year survival analysis. Methods: Patients with T3-T4 rectal cancer located within 10 cm from the anal verge. Radiotherapy protocol: 36 Gy, delivered in 12 daily doses of 3 Gy each for 5 days/week, followed by surgery after a 2-week break. Results: 263 patients were recruited. Radiotherapy was well tolerated. None of the patients broke off treatment. Complete histological response was 3% and maximum radio-induced downstaging 31.4%. Overall complication rate was 25.8% and direct radio-induced complications 0.4%. Mean duration of treatment was 35.7 days. In 172 patients with a minimum follow-up of 5 years, the rate of LR was 6.0% and DR 24.4%. Five-year overall survival was 70.2%, overall specific survival 78.0%, disease-free survival 70.7%, LR-free specific survival 92.9%, and DR-free specific survival 73.5%. Conclusions: In our experience, local disease control was achieved in 94% of patients. Any changes in our treatment protocols will aim at improving results in terms of LR and DR. In view of the four-fold higher rate of DR as compared to LR, improvement of DR can be defined as the challenge for the future.

KW - Locally advanced rectal cancer

KW - Neoadjuvant radiotherapy

KW - Total mesorectal excision

UR - http://www.scopus.com/inward/record.url?scp=77953679513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953679513&partnerID=8YFLogxK

U2 - 10.1159/000274459

DO - 10.1159/000274459

M3 - Article

VL - 27

SP - 217

EP - 223

JO - Digestive Surgery

JF - Digestive Surgery

SN - 0253-4886

IS - 3

ER -