Effectiveness of screening and treatment approaches for schistosomiasis and strongyloidiasis in newly-arrived migrants from endemic countries in the EU/EEA

A systematic review

Eric N. Agbata, Rachael L. Morton, Zeno Bisoffi, Emmanuel Bottieau, Christina Greenaway, Beverley A. Biggs, Nadia Montero, Anh Tran, Nick Rowbotham, Ingrid Arevalo-Rodriguez, Daniel T. Myran, Teymur Noori, Pablo Alonso-Coello, Kevin Pottie, Ana Requena-Méndez

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

We aimed to evaluate the evidence on screening and treatment for two parasitic infections—schistosomiasis and strongyloidiasis—among migrants from endemic countries arriving in the European Union and European Economic Area (EU/EEA). We conducted a systematic search of multiple databases to identify systematic reviews and meta-analyses published between 1 January 1993 and 30 May 2016 presenting evidence on diagnostic and treatment efficacy and cost-effectiveness. We conducted additional systematic search for individual studies published between 2010 and 2017. We assessed the methodological quality of reviews and studies using the AMSTAR, Newcastle–Ottawa Scale and QUADAS-II tools. Study synthesis and assessment of the certainty of the evidence was performed using GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. We included 28 systematic reviews and individual studies in this review. The GRADE certainty of evidence was low for the effectiveness of screening techniques and moderate to high for treatment efficacy. Antibody-detecting serological tests are the most effective screening tests for detection of both schistosomiasis and strongyloidiasis in low-endemicity settings, because they have higher sensitivity than conventional parasitological methods. Short courses of praziquantel and ivermectin were safe and highly effective and cost-effective in treating schistosomiasis and strongyloidiasis, respectively. Economic modelling suggests presumptive single-dose treatment of strongyloidiasis with ivermectin for all migrants is likely cost-effective, but feasibility of this strategy has yet to be demonstrated in clinical studies. The evidence supports screening and treatment for schistosomiasis and strongyloidiasis in migrants from endemic countries, to reduce morbidity and mortality.

Original languageEnglish
Article number11
JournalInternational Journal of Environmental Research and Public Health
Volume16
Issue number1
DOIs
Publication statusPublished - Dec 20 2018

Fingerprint

Strongyloidiasis
Schistosomiasis
European Union
Economics
Ivermectin
Costs and Cost Analysis
Praziquantel
Serologic Tests
Health Care Costs
Cost-Benefit Analysis
Meta-Analysis
Databases
Morbidity
Mortality
Antibodies

Keywords

  • Grade
  • Migrant populations
  • Public health
  • Schistosomiasis/schistosoma
  • Screening/diagnosis
  • Strongyloidiasis/strongyloides
  • Treatment

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Effectiveness of screening and treatment approaches for schistosomiasis and strongyloidiasis in newly-arrived migrants from endemic countries in the EU/EEA : A systematic review. / Agbata, Eric N.; Morton, Rachael L.; Bisoffi, Zeno; Bottieau, Emmanuel; Greenaway, Christina; Biggs, Beverley A.; Montero, Nadia; Tran, Anh; Rowbotham, Nick; Arevalo-Rodriguez, Ingrid; Myran, Daniel T.; Noori, Teymur; Alonso-Coello, Pablo; Pottie, Kevin; Requena-Méndez, Ana.

In: International Journal of Environmental Research and Public Health, Vol. 16, No. 1, 11, 20.12.2018.

Research output: Contribution to journalReview article

Agbata, EN, Morton, RL, Bisoffi, Z, Bottieau, E, Greenaway, C, Biggs, BA, Montero, N, Tran, A, Rowbotham, N, Arevalo-Rodriguez, I, Myran, DT, Noori, T, Alonso-Coello, P, Pottie, K & Requena-Méndez, A 2018, 'Effectiveness of screening and treatment approaches for schistosomiasis and strongyloidiasis in newly-arrived migrants from endemic countries in the EU/EEA: A systematic review', International Journal of Environmental Research and Public Health, vol. 16, no. 1, 11. https://doi.org/10.3390/ijerph16010011
Agbata, Eric N. ; Morton, Rachael L. ; Bisoffi, Zeno ; Bottieau, Emmanuel ; Greenaway, Christina ; Biggs, Beverley A. ; Montero, Nadia ; Tran, Anh ; Rowbotham, Nick ; Arevalo-Rodriguez, Ingrid ; Myran, Daniel T. ; Noori, Teymur ; Alonso-Coello, Pablo ; Pottie, Kevin ; Requena-Méndez, Ana. / Effectiveness of screening and treatment approaches for schistosomiasis and strongyloidiasis in newly-arrived migrants from endemic countries in the EU/EEA : A systematic review. In: International Journal of Environmental Research and Public Health. 2018 ; Vol. 16, No. 1.
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AU - Greenaway, Christina

AU - Biggs, Beverley A.

AU - Montero, Nadia

AU - Tran, Anh

AU - Rowbotham, Nick

AU - Arevalo-Rodriguez, Ingrid

AU - Myran, Daniel T.

AU - Noori, Teymur

AU - Alonso-Coello, Pablo

AU - Pottie, Kevin

AU - Requena-Méndez, Ana

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