Effectiveness of short-term administration of tibolone plus gonadotropin-releasing hormone analogue on the surgical outcome of laparoscopic myomectomy

Stefano Palomba, Massimiliano Pellicano, Pietro Affinito, Costantino Di Carlo, Fulvio Zullo, Carmine Nappi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: To evaluate whether administration of tibolone changes the effectiveness of GnRH analogue administered before laparoscopic myomectomy. Design: Prospective, randomized, open, placebo-controlled clinical trial. Setting: Department of Gynecology and Obstetrics, University of Naples 'Federico II,' Naples, Italy. Patient(s): 66 women with symptomatic uterine leiomyomas. Intervention(s): Treatment for 2 months with leuprolide acetate and iron tablets, plus tibolone (group A) or placebo tablets (group B); or with leuprolide acetate and iron tablets (group C). Main Outcome Measure(s): Laparoscopic myomectomy at the end of treatment. Operative time and blood loss during surgery were recorded. Uterine volume, volume and number of uterine leiomyomas, volume and echogenicity of the largest uterine leiomyomas, hematologic data, and myoma-related symptoms were evaluated at baseline and 1 week before and after surgery. Results: Uterine and leiomyomata volume and myoma-related symptoms were significantly reduced and hematologic variables improved significantly in groups A and B, compared with baseline values and with group C. Operative time and blood loss were significantly less in groups A and B than in group C. After surgery, hematologic variables were significantly worse in group C compared with groups A and B. During the study no significant difference was detected between groups A and B. Conclusions: Administration of tibolone administration in patients treated with GnRH analogue before laparoscopic myomectomy does not change the effectiveness of the analogue administered alone.

Original languageEnglish
Pages (from-to)429-433
Number of pages5
JournalFertility and Sterility
Volume75
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

tibolone
Uterine Myomectomy
Leiomyoma
Gonadotropin-Releasing Hormone
Tablets
Leuprolide
Myoma
Operative Time
Iron
Placebos
Hospital Obstetrics and Gynecology Department
Controlled Clinical Trials
Gynecology
Italy
Outcome Assessment (Health Care)
Therapeutics

Keywords

  • GnRH analogue
  • Leiomyoma
  • Myomectomy
  • Tibolone

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Effectiveness of short-term administration of tibolone plus gonadotropin-releasing hormone analogue on the surgical outcome of laparoscopic myomectomy. / Palomba, Stefano; Pellicano, Massimiliano; Affinito, Pietro; Di Carlo, Costantino; Zullo, Fulvio; Nappi, Carmine.

In: Fertility and Sterility, Vol. 75, No. 2, 2001, p. 429-433.

Research output: Contribution to journalArticle

Palomba, Stefano ; Pellicano, Massimiliano ; Affinito, Pietro ; Di Carlo, Costantino ; Zullo, Fulvio ; Nappi, Carmine. / Effectiveness of short-term administration of tibolone plus gonadotropin-releasing hormone analogue on the surgical outcome of laparoscopic myomectomy. In: Fertility and Sterility. 2001 ; Vol. 75, No. 2. pp. 429-433.
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N2 - Objective: To evaluate whether administration of tibolone changes the effectiveness of GnRH analogue administered before laparoscopic myomectomy. Design: Prospective, randomized, open, placebo-controlled clinical trial. Setting: Department of Gynecology and Obstetrics, University of Naples 'Federico II,' Naples, Italy. Patient(s): 66 women with symptomatic uterine leiomyomas. Intervention(s): Treatment for 2 months with leuprolide acetate and iron tablets, plus tibolone (group A) or placebo tablets (group B); or with leuprolide acetate and iron tablets (group C). Main Outcome Measure(s): Laparoscopic myomectomy at the end of treatment. Operative time and blood loss during surgery were recorded. Uterine volume, volume and number of uterine leiomyomas, volume and echogenicity of the largest uterine leiomyomas, hematologic data, and myoma-related symptoms were evaluated at baseline and 1 week before and after surgery. Results: Uterine and leiomyomata volume and myoma-related symptoms were significantly reduced and hematologic variables improved significantly in groups A and B, compared with baseline values and with group C. Operative time and blood loss were significantly less in groups A and B than in group C. After surgery, hematologic variables were significantly worse in group C compared with groups A and B. During the study no significant difference was detected between groups A and B. Conclusions: Administration of tibolone administration in patients treated with GnRH analogue before laparoscopic myomectomy does not change the effectiveness of the analogue administered alone.

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