Abstract
The published studies on histological staging and response to steroid therapy of membranous glomerulonephritis are not consistent. We analysed data from 25 adult patients with stage I (group 1, n = 7) and stage II (group 2, n = 18) disease. The interval between clinical onset and admission was similar in the two groups. At admission all patients had normal creatinine clearance; proteinuria averaged 5.4 ± 4.0 in group 1 and 9.0 ± 4.0 in group 2 (g/day per 100ml GFR). All patients received 6 months steroid therapy (months 1-2, 1 mg/kg b.w. per day; month 3-5: 0.65 mg/kg b.w. e.o.d.; month 6, tapering). After this cycle of steroid therapy, proteinuria declined by 84% in group 1 (five patients being in partial remission, i.e. 0.4-2 g/day, and two patients in complete remission, i.e. ≤0.3 g/day) and by 47% in group 2 (two patients being in complete remission and six in partial remission). Only 1 patient in group 1 relapsed with nephrotic proteinuria after 36 months, and renal function was still normal in all patients at the most recent follow-up (59 ± 32 months). In contrast, 14 patients in group 2 had nephrotic syndrome and seven renal insufficiency at the most recent follow-up. We conclude that short-term steroid therapy is effective only in patients with early membranous changes.
| Original language | English |
|---|---|
| Pages (from-to) | 1022-1029 |
| Number of pages | 8 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 4 |
| Issue number | 12 |
| Publication status | Published - 1989 |
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Keywords
- Histological stages
- membranous nephropathy
- Steroid therapy
ASJC Scopus subject areas
- Nephrology
- Transplantation
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Effectiveness of steroid therapy in different stages of membranous nephropathy. / Fuiano, G.; Stanziale, P.; Balletta, M.; Sepe, V.; Marinelli, G.; Comi, N.; Esposito, A.; Andreucci, V. E.
In: Nephrology Dialysis Transplantation, Vol. 4, No. 12, 1989, p. 1022-1029.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effectiveness of steroid therapy in different stages of membranous nephropathy
AU - Fuiano, G.
AU - Stanziale, P.
AU - Balletta, M.
AU - Sepe, V.
AU - Marinelli, G.
AU - Comi, N.
AU - Esposito, A.
AU - Andreucci, V. E.
PY - 1989
Y1 - 1989
N2 - The published studies on histological staging and response to steroid therapy of membranous glomerulonephritis are not consistent. We analysed data from 25 adult patients with stage I (group 1, n = 7) and stage II (group 2, n = 18) disease. The interval between clinical onset and admission was similar in the two groups. At admission all patients had normal creatinine clearance; proteinuria averaged 5.4 ± 4.0 in group 1 and 9.0 ± 4.0 in group 2 (g/day per 100ml GFR). All patients received 6 months steroid therapy (months 1-2, 1 mg/kg b.w. per day; month 3-5: 0.65 mg/kg b.w. e.o.d.; month 6, tapering). After this cycle of steroid therapy, proteinuria declined by 84% in group 1 (five patients being in partial remission, i.e. 0.4-2 g/day, and two patients in complete remission, i.e. ≤0.3 g/day) and by 47% in group 2 (two patients being in complete remission and six in partial remission). Only 1 patient in group 1 relapsed with nephrotic proteinuria after 36 months, and renal function was still normal in all patients at the most recent follow-up (59 ± 32 months). In contrast, 14 patients in group 2 had nephrotic syndrome and seven renal insufficiency at the most recent follow-up. We conclude that short-term steroid therapy is effective only in patients with early membranous changes.
AB - The published studies on histological staging and response to steroid therapy of membranous glomerulonephritis are not consistent. We analysed data from 25 adult patients with stage I (group 1, n = 7) and stage II (group 2, n = 18) disease. The interval between clinical onset and admission was similar in the two groups. At admission all patients had normal creatinine clearance; proteinuria averaged 5.4 ± 4.0 in group 1 and 9.0 ± 4.0 in group 2 (g/day per 100ml GFR). All patients received 6 months steroid therapy (months 1-2, 1 mg/kg b.w. per day; month 3-5: 0.65 mg/kg b.w. e.o.d.; month 6, tapering). After this cycle of steroid therapy, proteinuria declined by 84% in group 1 (five patients being in partial remission, i.e. 0.4-2 g/day, and two patients in complete remission, i.e. ≤0.3 g/day) and by 47% in group 2 (two patients being in complete remission and six in partial remission). Only 1 patient in group 1 relapsed with nephrotic proteinuria after 36 months, and renal function was still normal in all patients at the most recent follow-up (59 ± 32 months). In contrast, 14 patients in group 2 had nephrotic syndrome and seven renal insufficiency at the most recent follow-up. We conclude that short-term steroid therapy is effective only in patients with early membranous changes.
KW - Histological stages
KW - membranous nephropathy
KW - Steroid therapy
UR - http://www.scopus.com/inward/record.url?scp=0024916304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024916304&partnerID=8YFLogxK
M3 - Article
C2 - 2517322
AN - SCOPUS:0024916304
VL - 4
SP - 1022
EP - 1029
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
SN - 0931-0509
IS - 12
ER -