Effectiveness of steroid therapy in different stages of membranous nephropathy

G. Fuiano, P. Stanziale, M. Balletta, V. Sepe, G. Marinelli, N. Comi, A. Esposito, V. E. Andreucci

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The published studies on histological staging and response to steroid therapy of membranous glomerulonephritis are not consistent. We analysed data from 25 adult patients with stage I (group 1, n = 7) and stage II (group 2, n = 18) disease. The interval between clinical onset and admission was similar in the two groups. At admission all patients had normal creatinine clearance; proteinuria averaged 5.4 ± 4.0 in group 1 and 9.0 ± 4.0 in group 2 (g/day per 100ml GFR). All patients received 6 months steroid therapy (months 1-2, 1 mg/kg b.w. per day; month 3-5: 0.65 mg/kg b.w. e.o.d.; month 6, tapering). After this cycle of steroid therapy, proteinuria declined by 84% in group 1 (five patients being in partial remission, i.e. 0.4-2 g/day, and two patients in complete remission, i.e. ≤0.3 g/day) and by 47% in group 2 (two patients being in complete remission and six in partial remission). Only 1 patient in group 1 relapsed with nephrotic proteinuria after 36 months, and renal function was still normal in all patients at the most recent follow-up (59 ± 32 months). In contrast, 14 patients in group 2 had nephrotic syndrome and seven renal insufficiency at the most recent follow-up. We conclude that short-term steroid therapy is effective only in patients with early membranous changes.

Original languageEnglish
Pages (from-to)1022-1029
Number of pages8
JournalNephrology Dialysis Transplantation
Volume4
Issue number12
Publication statusPublished - 1989

Fingerprint

Membranous Glomerulonephritis
Steroids
Proteinuria
Therapeutics
Patient Admission
Nephrotic Syndrome
Renal Insufficiency
Creatinine
Kidney

Keywords

  • Histological stages
  • membranous nephropathy
  • Steroid therapy

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Fuiano, G., Stanziale, P., Balletta, M., Sepe, V., Marinelli, G., Comi, N., ... Andreucci, V. E. (1989). Effectiveness of steroid therapy in different stages of membranous nephropathy. Nephrology Dialysis Transplantation, 4(12), 1022-1029.

Effectiveness of steroid therapy in different stages of membranous nephropathy. / Fuiano, G.; Stanziale, P.; Balletta, M.; Sepe, V.; Marinelli, G.; Comi, N.; Esposito, A.; Andreucci, V. E.

In: Nephrology Dialysis Transplantation, Vol. 4, No. 12, 1989, p. 1022-1029.

Research output: Contribution to journalArticle

Fuiano, G, Stanziale, P, Balletta, M, Sepe, V, Marinelli, G, Comi, N, Esposito, A & Andreucci, VE 1989, 'Effectiveness of steroid therapy in different stages of membranous nephropathy', Nephrology Dialysis Transplantation, vol. 4, no. 12, pp. 1022-1029.
Fuiano G, Stanziale P, Balletta M, Sepe V, Marinelli G, Comi N et al. Effectiveness of steroid therapy in different stages of membranous nephropathy. Nephrology Dialysis Transplantation. 1989;4(12):1022-1029.
Fuiano, G. ; Stanziale, P. ; Balletta, M. ; Sepe, V. ; Marinelli, G. ; Comi, N. ; Esposito, A. ; Andreucci, V. E. / Effectiveness of steroid therapy in different stages of membranous nephropathy. In: Nephrology Dialysis Transplantation. 1989 ; Vol. 4, No. 12. pp. 1022-1029.
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