L'efficacia dell'associazione tra farmaci e Reality Orientation Therapy

Cholinesterase inhibitors are indicated for the symptomatic treatment of mild-to-moderate Alzheimer's Disease because they slow the progression of the disease. Its efficacy and safety have been demonstrated in placebo-controlled trials for ut to one year. By now, non-pharmachological interventions are also available; Reality Orientation Therapy (ROT) is the only one clearly effective as a Cochrane Library review has shown. A recent meta-analysis concluded that the ROT could improve both the cognitive performances and the behavioural disturbances. So, the ROT is the best candidate to be included in the therapy of Alzheimer's Disease. Recent studies have shown that the association of ROT to drug therapy can benefit more cognition than colinesterase inhibitor alone.