Effectiveness of the mediterranean diet: Can it help delay or prevent Alzheimer's disease?

Francesco Sofi, Claudio Macchi, Rosanna Abbate, Gian Franco Gensini, Alessandro Casini

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease characterized by cognitive and memory deterioration, with an increasing prevalence in the industrialized countries and an extraordinary cost of caring for patients. Due to the limited information available on the exact pathophysiology of the disease, over the last years there have been extensive efforts on the identification of possible risk factors, but no conclusive data have been obtained. Some risk factors have been identified but no clear evidence on what is clearly associated with the occurrence and progression of AD are available, and in particular no effective preventive strategies have been found. One of the most intriguing and appealing lines of investigation is the association between lifestyle habits such as diet and dietary compounds and the occurrence of AD. In this review, we focus on studies that investigated the association between nutrition and AD, paying particular attention to the role of a dietary pattern such as a Mediterranean-like diet on the occurrence of such disease. Studies in support of Mediterranean diet as an optimal diet for prevention of cardiovascular and major chronic diseases has rapidly evolved. A recent meta-analysis from our group, comprising prospective studies that investigated the association between adherence to Mediterranean diet and health status, showed a significant association between a greater adherence to Mediterranean diet and a reduced risk of major chronic degenerative diseases, including AD. Moreover, the Mediterranean diet has been extensively reported to be associated with a favorable health outcome and a better quality of life.

Original languageEnglish
Pages (from-to)795-801
Number of pages7
JournalJournal of Alzheimer's Disease
Volume20
Issue number3
DOIs
Publication statusPublished - 2010

Fingerprint

Mediterranean Diet
Alzheimer Disease
Chronic Disease
Diet
Developed Countries
Neurodegenerative Diseases
Health Status
Habits
Meta-Analysis
Life Style
Quality of Life
Prospective Studies
Costs and Cost Analysis
Health

Keywords

  • Alzheimer's disease
  • health
  • Mediterranean diet
  • nutrition

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Effectiveness of the mediterranean diet : Can it help delay or prevent Alzheimer's disease? / Sofi, Francesco; Macchi, Claudio; Abbate, Rosanna; Gensini, Gian Franco; Casini, Alessandro.

In: Journal of Alzheimer's Disease, Vol. 20, No. 3, 2010, p. 795-801.

Research output: Contribution to journalArticle

Sofi, Francesco ; Macchi, Claudio ; Abbate, Rosanna ; Gensini, Gian Franco ; Casini, Alessandro. / Effectiveness of the mediterranean diet : Can it help delay or prevent Alzheimer's disease?. In: Journal of Alzheimer's Disease. 2010 ; Vol. 20, No. 3. pp. 795-801.
@article{7647e4a4cdb740649061061e07bc2bb6,
title = "Effectiveness of the mediterranean diet: Can it help delay or prevent Alzheimer's disease?",
abstract = "Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease characterized by cognitive and memory deterioration, with an increasing prevalence in the industrialized countries and an extraordinary cost of caring for patients. Due to the limited information available on the exact pathophysiology of the disease, over the last years there have been extensive efforts on the identification of possible risk factors, but no conclusive data have been obtained. Some risk factors have been identified but no clear evidence on what is clearly associated with the occurrence and progression of AD are available, and in particular no effective preventive strategies have been found. One of the most intriguing and appealing lines of investigation is the association between lifestyle habits such as diet and dietary compounds and the occurrence of AD. In this review, we focus on studies that investigated the association between nutrition and AD, paying particular attention to the role of a dietary pattern such as a Mediterranean-like diet on the occurrence of such disease. Studies in support of Mediterranean diet as an optimal diet for prevention of cardiovascular and major chronic diseases has rapidly evolved. A recent meta-analysis from our group, comprising prospective studies that investigated the association between adherence to Mediterranean diet and health status, showed a significant association between a greater adherence to Mediterranean diet and a reduced risk of major chronic degenerative diseases, including AD. Moreover, the Mediterranean diet has been extensively reported to be associated with a favorable health outcome and a better quality of life.",
keywords = "Alzheimer's disease, health, Mediterranean diet, nutrition",
author = "Francesco Sofi and Claudio Macchi and Rosanna Abbate and Gensini, {Gian Franco} and Alessandro Casini",
year = "2010",
doi = "10.3233/JAD-2010-1418",
language = "English",
volume = "20",
pages = "795--801",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "3",

}

TY - JOUR

T1 - Effectiveness of the mediterranean diet

T2 - Can it help delay or prevent Alzheimer's disease?

AU - Sofi, Francesco

AU - Macchi, Claudio

AU - Abbate, Rosanna

AU - Gensini, Gian Franco

AU - Casini, Alessandro

PY - 2010

Y1 - 2010

N2 - Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease characterized by cognitive and memory deterioration, with an increasing prevalence in the industrialized countries and an extraordinary cost of caring for patients. Due to the limited information available on the exact pathophysiology of the disease, over the last years there have been extensive efforts on the identification of possible risk factors, but no conclusive data have been obtained. Some risk factors have been identified but no clear evidence on what is clearly associated with the occurrence and progression of AD are available, and in particular no effective preventive strategies have been found. One of the most intriguing and appealing lines of investigation is the association between lifestyle habits such as diet and dietary compounds and the occurrence of AD. In this review, we focus on studies that investigated the association between nutrition and AD, paying particular attention to the role of a dietary pattern such as a Mediterranean-like diet on the occurrence of such disease. Studies in support of Mediterranean diet as an optimal diet for prevention of cardiovascular and major chronic diseases has rapidly evolved. A recent meta-analysis from our group, comprising prospective studies that investigated the association between adherence to Mediterranean diet and health status, showed a significant association between a greater adherence to Mediterranean diet and a reduced risk of major chronic degenerative diseases, including AD. Moreover, the Mediterranean diet has been extensively reported to be associated with a favorable health outcome and a better quality of life.

AB - Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease characterized by cognitive and memory deterioration, with an increasing prevalence in the industrialized countries and an extraordinary cost of caring for patients. Due to the limited information available on the exact pathophysiology of the disease, over the last years there have been extensive efforts on the identification of possible risk factors, but no conclusive data have been obtained. Some risk factors have been identified but no clear evidence on what is clearly associated with the occurrence and progression of AD are available, and in particular no effective preventive strategies have been found. One of the most intriguing and appealing lines of investigation is the association between lifestyle habits such as diet and dietary compounds and the occurrence of AD. In this review, we focus on studies that investigated the association between nutrition and AD, paying particular attention to the role of a dietary pattern such as a Mediterranean-like diet on the occurrence of such disease. Studies in support of Mediterranean diet as an optimal diet for prevention of cardiovascular and major chronic diseases has rapidly evolved. A recent meta-analysis from our group, comprising prospective studies that investigated the association between adherence to Mediterranean diet and health status, showed a significant association between a greater adherence to Mediterranean diet and a reduced risk of major chronic degenerative diseases, including AD. Moreover, the Mediterranean diet has been extensively reported to be associated with a favorable health outcome and a better quality of life.

KW - Alzheimer's disease

KW - health

KW - Mediterranean diet

KW - nutrition

UR - http://www.scopus.com/inward/record.url?scp=77953700872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953700872&partnerID=8YFLogxK

U2 - 10.3233/JAD-2010-1418

DO - 10.3233/JAD-2010-1418

M3 - Article

C2 - 20182044

AN - SCOPUS:77953700872

VL - 20

SP - 795

EP - 801

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 3

ER -