EFFICACIA DELLE MISURE UNIVERSALI NELLA PREVENZIONE DELL'INFEZIONE NOSOCOMIALE DA HCV IN EMODIALISI

RISULTATI DI UNO STUDIO PROSPETTICO

Translated title of the contribution: Effectiveness of universal precautions in limiting nosocomial infection of hepatitis C virus in haemodialysis

F. Aucella, G. L. Valente, M. Di Tullio, M. Centra, E. Martini, G. Di Giorgio, C. Stallone

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In order to evaluate the incidence of hepatitis C virus (HCV) infection in haemodialysis, we studied the population of three dialysis units without segregation of anti-HCV positive patients. An anti-HCV test (2nd generation Elisa) was prospectively performed on 88 patients on RDT every 4 months from April 1991 to October 1994. Second generation Riba and HCV-RNA by PCR were used in positive subjects. General precautions, as in Center for Disease Control Recommendations, were applied in avoiding nosocomial transmission, but no special measure was set up. Mean follow-up was 37.2 months. Anti-HCV Ab were initially detected in 32 (35.2%) patients; during the follow-up HCV seroconversion was observed in 1 of 56 (1.7%), 2 of 55 (3.6%) and 2 of 53 (3.7%): thus the mean incidence in the follow-up period was 2.79% years. All seroconverted patients were HCV-RNA positive and 4/5 had a Riba positive test. 3/5 were dialyzed on the same monitor of anti-HCV positive subjects, one was transfused 15 months before seroconversion and one was dialyzed next to a positive patient. Despite a high prevalence of HCV infection, general precautions without segregation showed a fairly good efficacy in limiting nosocomial HCV transmission. Seroconversion seems to be either horizontal, patient-patient, and vertical, through monitors. Simple measure, such as monitors' disinfection after each dialysis session, may improve these results.

Original languageItalian
Pages (from-to)373-379
Number of pages7
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume12
Issue number6
Publication statusPublished - 1995

Fingerprint

Universal Precautions
Cross Infection
Hepacivirus
Renal Dialysis
Virus Diseases
Dialysis
RNA
Disinfection
Incidence
Centers for Disease Control and Prevention (U.S.)

ASJC Scopus subject areas

  • Nephrology

Cite this

EFFICACIA DELLE MISURE UNIVERSALI NELLA PREVENZIONE DELL'INFEZIONE NOSOCOMIALE DA HCV IN EMODIALISI : RISULTATI DI UNO STUDIO PROSPETTICO. / Aucella, F.; Valente, G. L.; Di Tullio, M.; Centra, M.; Martini, E.; Di Giorgio, G.; Stallone, C.

In: Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, Vol. 12, No. 6, 1995, p. 373-379.

Research output: Contribution to journalArticle

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abstract = "In order to evaluate the incidence of hepatitis C virus (HCV) infection in haemodialysis, we studied the population of three dialysis units without segregation of anti-HCV positive patients. An anti-HCV test (2nd generation Elisa) was prospectively performed on 88 patients on RDT every 4 months from April 1991 to October 1994. Second generation Riba and HCV-RNA by PCR were used in positive subjects. General precautions, as in Center for Disease Control Recommendations, were applied in avoiding nosocomial transmission, but no special measure was set up. Mean follow-up was 37.2 months. Anti-HCV Ab were initially detected in 32 (35.2{\%}) patients; during the follow-up HCV seroconversion was observed in 1 of 56 (1.7{\%}), 2 of 55 (3.6{\%}) and 2 of 53 (3.7{\%}): thus the mean incidence in the follow-up period was 2.79{\%} years. All seroconverted patients were HCV-RNA positive and 4/5 had a Riba positive test. 3/5 were dialyzed on the same monitor of anti-HCV positive subjects, one was transfused 15 months before seroconversion and one was dialyzed next to a positive patient. Despite a high prevalence of HCV infection, general precautions without segregation showed a fairly good efficacy in limiting nosocomial HCV transmission. Seroconversion seems to be either horizontal, patient-patient, and vertical, through monitors. Simple measure, such as monitors' disinfection after each dialysis session, may improve these results.",
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