Effects during and after treatment of hypertension with guanfacine: A controlled clinical trial in comparison with alpha-methyldopa

M. Meregalli, E. Guffanti, G. Fiorella

Research output: Contribution to journalArticlepeer-review

Abstract

Forty-five patients with mild-to-moderate hypertension completed a random clinical trial designed to evaluate the effectiveness and side effects of guanfacine and alpha-methyldopa during a 12-week period and after withdrawal. Blood pressures were significantly reduced in both groups; addition of a diuretic was required by 12 patients of the guanfacine group, and 17 of the alpha-methyldopa group. During the treatment period, the frequencies of side effects were comparable in both groups. After sudden cessation of either alpha-methyldopa or guanfacine therapy, there were no significant early rebound phenomena. All the parameters tended to increase gradually, reaching pretreatment values or remaining lower up to the 5th day. Only 5 patients in each group complained of one or more side effects. It was concluded that there are close similarities between the effects of guanfacine and alpha-methyldopa on the parameters evaluated, both during active treatments and after their abrupt discontinuation.

Original languageEnglish
Pages (from-to)174-182
Number of pages9
JournalCurrent Therapeutic Research
Volume34
Issue number1 II
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Medicine(all)

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