Forty-five patients with mild-to-moderate hypertension completed a random clinical trial designed to evaluate the effectiveness and side effects of guanfacine and alpha-methyldopa during a 12-week period and after withdrawal. Blood pressures were significantly reduced in both groups; addition of a diuretic was required by 12 patients of the guanfacine group, and 17 of the alpha-methyldopa group. During the treatment period, the frequencies of side effects were comparable in both groups. After sudden cessation of either alpha-methyldopa or guanfacine therapy, there were no significant early rebound phenomena. All the parameters tended to increase gradually, reaching pretreatment values or remaining lower up to the 5th day. Only 5 patients in each group complained of one or more side effects. It was concluded that there are close similarities between the effects of guanfacine and alpha-methyldopa on the parameters evaluated, both during active treatments and after their abrupt discontinuation.
|Number of pages||9|
|Journal||Current Therapeutic Research|
|Issue number||1 II|
|Publication status||Published - 1983|
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