Effects of 1 gram oral or intravenous aspirin on urinary excretion of thromboxane B2 and 6-keto-PGF1α in healthy subjects

Francesca Bucchi, Anna Bodzenta, Giovanni de Gaetano, Chiara Cerletti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aspirin inhibits cyclo-oxygenase, thus preventing prostanoids formation. After oral administration aspirin is hydrolysed to inactive salicylate partly within the gastrointestinal tract, partly during first pass in the liver, partly in the circulation by plasma esterases. Intravenous aspirin, in contrast, mainly undergoes plasma esterase-catalysed deacetylation. Six healthy male subjects were given 1 g aspirin orally and intravenously two weeks apart according to a cross-over randomized design. Whereas serum T×B2 generation reflecting platelet cyclo-oxygenase activity was suppressed by aspirin by both routes, urinary excretion of T×B2 and 6-keto-PGF1α was not affected by oral aspirin, but was partially though significantly reduced by the i.v. drug. Drug disposition seems therefore to be essential in determining the "biochemical selectivity" of aspirin as related to platelet and renal prostanoids generation.

Original languageEnglish
Pages (from-to)691-701
Number of pages11
JournalProstaglandins
Volume32
Issue number5
DOIs
Publication statusPublished - 1986

Fingerprint

Thromboxane B2
Aspirin
Healthy Volunteers
Esterases
Prostaglandin-Endoperoxide Synthases
Platelets
Prostaglandins
Blood Platelets
Plasmas
Salicylates
prostaglandin F1
Pharmaceutical Preparations
Liver
Cross-Over Studies
Oral Administration
Gastrointestinal Tract
Kidney
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Effects of 1 gram oral or intravenous aspirin on urinary excretion of thromboxane B2 and 6-keto-PGF1α in healthy subjects. / Bucchi, Francesca; Bodzenta, Anna; de Gaetano, Giovanni; Cerletti, Chiara.

In: Prostaglandins, Vol. 32, No. 5, 1986, p. 691-701.

Research output: Contribution to journalArticle

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