Effects of 12 months rec-GH therapy on bone and collagen turnover and bone mineral density in GH deficient children with thalassaemia major

Alessandro Sartorio, G. Conte, A. Conti, A. Masala, S. Alagna, P. Rovasio, G. Faglia

Research output: Contribution to journalArticle

Abstract

Children suffering from thalassaemia major are reported to have growth delay and bone alterations even when well transfused and chelated. In the present study we evaluated bone and collagen turnover (bone Gla-protein, BGP; carboxyterminal telopeptide of type I collagen, ICTP; amino-terminal propeptide of type III procollagen, PIIINP, respectively) and bone mineral density (BMD) in 5 pre-pubertal GH deficient thalassaemic children before and during rec-GH treatment (0.6 IU/kg/week). Data were compared with those recorded in an age- and sex-matched control group. Before treatment, serum BGP and ICTP levels were significantly lower (p2) were significantly lower (p2), while femoral BMD values were similar in the two groups (patients: 0.70±0.08 g/cm2 vs controls: 0.74±0.01 g/cm2). One-year GH therapy significantly increased height velocity (from 2.3±0.2 cm/year to 6.1±0.4 cm/yr, p

Original languageEnglish
Pages (from-to)356-361
Number of pages6
JournalJournal of Endocrinological Investigation
Volume23
Issue number6
Publication statusPublished - 2000

Keywords

  • Bone density
  • Bone turnover
  • Collagen turnover
  • GH
  • GH deficiency
  • Thalassaemia

ASJC Scopus subject areas

  • Endocrinology

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