Effects of 17β-estradiol, progesterone and tamoxifen on in vitro proliferation of human pituitary adenomas: Correlation with specific cellular receptors

Brunella Caronti; Guido Palladini; Maria Gabriella Bevitacqua; Elisa Petrangeli; Bernardo Fraioli; Giampaolo Cantore; Guido Tamburrano; Carmine Maria Carapella; Marie Lis Jffrain-Rea

doi:10.1159/000217826

Effects of 17β-estradiol, progesterone and tamoxifen on in vitro proliferation of human pituitary adenomas: Correlation with specific cellular receptors

Brunella Caronti, Guido Palladini, Maria Gabriella Bevitacqua, Elisa Petrangeli, Bernardo Fraioli, Giampaolo Cantore, Guido Tamburrano, Carmine Maria Carapella, Marie Lis Jffrain-Rea

Research output: Contribution to journal › Article › peer-review

Abstract

Six human pituitary adenoma cultures, characterized for estrogen and progesterone (Pg) receptors, were treated with 17ß- estradiol (17β-Ε₂), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in most cases a stimulating effect of 17ß-E₂ and an inhibitory effect of Pg on cell growth, which appeared to be correlated with specific receptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expression.

Original language	English
Pages (from-to)	59-68
Number of pages	10
Journal	Tumor Biology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1159/000217826
Publication status	Published - 1993

Keywords

Antiestrogens
Cell cultures
Pituitary neoplasms
Steroid hormones
Steroid receptors

ASJC Scopus subject areas

Cancer Research

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Effects of 17β-estradiol, progesterone and tamoxifen on in vitro proliferation of human pituitary adenomas : Correlation with specific cellular receptors. / Caronti, Brunella; Palladini, Guido; Bevitacqua, Maria Gabriella; Petrangeli, Elisa; Fraioli, Bernardo; Cantore, Giampaolo; Tamburrano, Guido; Carapella, Carmine Maria; Jffrain-Rea, Marie Lis.

In: Tumor Biology, Vol. 14, No. 1, 1993, p. 59-68.

Research output: Contribution to journal › Article › peer-review

Caronti, Brunella ; Palladini, Guido ; Bevitacqua, Maria Gabriella ; Petrangeli, Elisa ; Fraioli, Bernardo ; Cantore, Giampaolo ; Tamburrano, Guido ; Carapella, Carmine Maria ; Jffrain-Rea, Marie Lis. / Effects of 17β-estradiol, progesterone and tamoxifen on in vitro proliferation of human pituitary adenomas : Correlation with specific cellular receptors. In: Tumor Biology. 1993 ; Vol. 14, No. 1. pp. 59-68.

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