TY - JOUR
T1 - Effects of 17β-estradiol, progesterone and tamoxifen on in vitro proliferation of human pituitary adenomas
T2 - Correlation with specific cellular receptors
AU - Caronti, Brunella
AU - Palladini, Guido
AU - Bevitacqua, Maria Gabriella
AU - Petrangeli, Elisa
AU - Fraioli, Bernardo
AU - Cantore, Giampaolo
AU - Tamburrano, Guido
AU - Carapella, Carmine Maria
AU - Jffrain-Rea, Marie Lis
PY - 1993
Y1 - 1993
N2 - Six human pituitary adenoma cultures, characterized for estrogen and progesterone (Pg) receptors, were treated with 17ß- estradiol (17β-Ε2), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in most cases a stimulating effect of 17ß-E2 and an inhibitory effect of Pg on cell growth, which appeared to be correlated with specific receptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expression.
AB - Six human pituitary adenoma cultures, characterized for estrogen and progesterone (Pg) receptors, were treated with 17ß- estradiol (17β-Ε2), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in most cases a stimulating effect of 17ß-E2 and an inhibitory effect of Pg on cell growth, which appeared to be correlated with specific receptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expression.
KW - Antiestrogens
KW - Cell cultures
KW - Pituitary neoplasms
KW - Steroid hormones
KW - Steroid receptors
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U2 - 10.1159/000217826
DO - 10.1159/000217826
M3 - Article
C2 - 8493452
AN - SCOPUS:0027161745
VL - 14
SP - 59
EP - 68
JO - Tumor Biology
JF - Tumor Biology
SN - 1010-4283
IS - 1
ER -