Effects of 17β-estradiol, progesterone and tamoxifen on in vitro proliferation of human pituitary adenomas: Correlation with specific cellular receptors

Brunella Caronti, Guido Palladini, Maria Gabriella Bevitacqua, Elisa Petrangeli, Bernardo Fraioli, Giampaolo Cantore, Guido Tamburrano, Carmine Maria Carapella, Marie Lis Jffrain-Rea

Research output: Contribution to journalArticlepeer-review

Abstract

Six human pituitary adenoma cultures, characterized for estrogen and progesterone (Pg) receptors, were treated with 17ß- estradiol (17β-Ε2), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in most cases a stimulating effect of 17ß-E2 and an inhibitory effect of Pg on cell growth, which appeared to be correlated with specific receptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expression.

Original languageEnglish
Pages (from-to)59-68
Number of pages10
JournalTumor Biology
Volume14
Issue number1
DOIs
Publication statusPublished - 1993

Keywords

  • Antiestrogens
  • Cell cultures
  • Pituitary neoplasms
  • Steroid hormones
  • Steroid receptors

ASJC Scopus subject areas

  • Cancer Research

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