Effects of 3′-hydroxyfarrerol (IdB 1031), a novel flavonoid agent, on phagocyte products

Federica Meloni, Piercarla Ballabio, Marina Gorrini, Mara De Amici, Carlo Marena, Salvatore Malandrino, Maurizio Luisetti

Research output: Contribution to journalArticlepeer-review

Abstract

The novel flavonoid compound 3′-hydroxyfarrerol (IdB 1031) was tested in a number of in vitro experiments in order to ascertain its effects on some functions and products of human phagocytes. We found that IdB 1031 did not depress neutrophil phagocytosis and chemotaxis, whereas at a concentration of 10-4 M it significantly (p}i 200 μm). Finally, IdB 1031 at the concentration of 10-5 M significantly reduced the release of tumor necrosis factor-α and interleukin-8 from monocytes (p <0.05). We conclude that, in spite of the moderate activity displayed by IdB 1031, these findings add to our current knowledge on the spectrum of the antiinflammatory activities of flavonoids.

Original languageEnglish
Pages (from-to)689-699
Number of pages11
JournalInflammation
Volume19
Issue number6
DOIs
Publication statusPublished - Dec 1995

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology
  • Cell Biology

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