The novel flavonoid compound 3′-hydroxyfarrerol (IdB 1031) was tested in a number of in vitro experiments in order to ascertain its effects on some functions and products of human phagocytes. We found that IdB 1031 did not depress neutrophil phagocytosis and chemotaxis, whereas at a concentration of 10-4 M it significantly (p}i 200 μm). Finally, IdB 1031 at the concentration of 10-5 M significantly reduced the release of tumor necrosis factor-α and interleukin-8 from monocytes (p <0.05). We conclude that, in spite of the moderate activity displayed by IdB 1031, these findings add to our current knowledge on the spectrum of the antiinflammatory activities of flavonoids.
ASJC Scopus subject areas
- Cell Biology