The effects of acute 5-HT2 blockade with ketanserin, a new serotonin antagonist that specifically inhibits the 5-HT2 receptors, was compared in a placebo-controlled crossover study of ventilatory changes during exercise in 10 chronic airway obstructed patients. At rest, heart rate was increased following the administration of ketanserin as compared to placebo, while oxygen uptake (V̇(O2)), carbon dioxide output (V̇(CO2)) and O2-pulse were significantly lower. At heavy loads, tidal volume (V(T)) was significantly lower after 5-HT2 blockade while respiratory frequency (f(R)) was significantly higher following ketanserin. At 100 work units (W) ketanserin produced no significant reduction in ventilation exchange (V̇(E)), oxygen consumption (V̇(O2)), carbon dioxide production (V̇(CO2)), respiration (R), and O2-pulse, while ventilation exchange/energy quotient (V̇(E)/EQ) and metabolic equivalent of the tasks (METs) was unaffected and heart rate was increased. Ketanserin also induced a beneficial effect on arterial O2 demand during the exercise, until the maximal load levels (double product was lower after ketanserin).
|Number of pages||10|
|Journal||Advances in Therapy|
|Publication status||Published - 1987|
ASJC Scopus subject areas