Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors

Gloria Cristalli; Gian Marco Podda; Stefano Costanzi; Catia Lambertucci; Anna Lecchi; Sauro Vittori; Rosaria Volpini; Maddalena L. Zighetti; Marco Cattaneo

doi:10.1021/jm0493562

Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors

Gloria Cristalli, Gian Marco Podda, Stefano Costanzi, Catia Lambertucci, Anna Lecchi, Sauro Vittori, Rosaria Volpini, Maddalena L. Zighetti, Marco Cattaneo

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Newly synthesized mono-, di-, and triphosphate of 2-alkynyl adenosines showed very different behavior in human platelet P2Y receptor models, according to the different alkynyl chains. In fact, 2-hexynyladenosine di- (5) and triphosphate (7) induced platelet shape change and aggregation and inhibited PGE₁-induced increase in platelet cyclic AMP. On the contrary, the corresponding 2-phenylethynyladenosine di- (6) and triphosphate (8) did not induce platelet shape change or aggregation, but inhibited platelet aggregation induced by ADP.

Original language	English
Pages (from-to)	2763-2766
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	48
Issue number	8
DOIs	https://doi.org/10.1021/jm0493562
Publication status	Published - Apr 21 2005

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1021/jm0493562

Fingerprint Dive into the research topics of 'Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors'. Together they form a unique fingerprint.

Cite this

Cristalli, G., Podda, G. M., Costanzi, S., Lambertucci, C., Lecchi, A., Vittori, S., Volpini, R., Zighetti, M. L., & Cattaneo, M. (2005). Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors. Journal of Medicinal Chemistry, 48(8), 2763-2766. https://doi.org/10.1021/jm0493562

Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors. / Cristalli, Gloria; Podda, Gian Marco; Costanzi, Stefano; Lambertucci, Catia; Lecchi, Anna; Vittori, Sauro; Volpini, Rosaria; Zighetti, Maddalena L.; Cattaneo, Marco.

In: Journal of Medicinal Chemistry, Vol. 48, No. 8, 21.04.2005, p. 2763-2766.

Research output: Contribution to journal › Article › peer-review

Cristalli, G, Podda, GM, Costanzi, S, Lambertucci, C, Lecchi, A, Vittori, S, Volpini, R, Zighetti, ML & Cattaneo, M 2005, 'Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors', Journal of Medicinal Chemistry, vol. 48, no. 8, pp. 2763-2766. https://doi.org/10.1021/jm0493562

Cristalli, Gloria ; Podda, Gian Marco ; Costanzi, Stefano ; Lambertucci, Catia ; Lecchi, Anna ; Vittori, Sauro ; Volpini, Rosaria ; Zighetti, Maddalena L. ; Cattaneo, Marco. / Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors. In: Journal of Medicinal Chemistry. 2005 ; Vol. 48, No. 8. pp. 2763-2766.

@article{590e0b992e99410a88960801bcc831e7,

title = "Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors",

abstract = "Newly synthesized mono-, di-, and triphosphate of 2-alkynyl adenosines showed very different behavior in human platelet P2Y receptor models, according to the different alkynyl chains. In fact, 2-hexynyladenosine di- (5) and triphosphate (7) induced platelet shape change and aggregation and inhibited PGE1-induced increase in platelet cyclic AMP. On the contrary, the corresponding 2-phenylethynyladenosine di- (6) and triphosphate (8) did not induce platelet shape change or aggregation, but inhibited platelet aggregation induced by ADP.",

author = "Gloria Cristalli and Podda, {Gian Marco} and Stefano Costanzi and Catia Lambertucci and Anna Lecchi and Sauro Vittori and Rosaria Volpini and Zighetti, {Maddalena L.} and Marco Cattaneo",

year = "2005",

month = apr,

day = "21",

doi = "10.1021/jm0493562",

language = "English",

volume = "48",

pages = "2763--2766",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors

AU - Cristalli, Gloria

AU - Podda, Gian Marco

AU - Costanzi, Stefano

AU - Lambertucci, Catia

AU - Lecchi, Anna

AU - Vittori, Sauro

AU - Volpini, Rosaria

AU - Zighetti, Maddalena L.

AU - Cattaneo, Marco

PY - 2005/4/21

Y1 - 2005/4/21

N2 - Newly synthesized mono-, di-, and triphosphate of 2-alkynyl adenosines showed very different behavior in human platelet P2Y receptor models, according to the different alkynyl chains. In fact, 2-hexynyladenosine di- (5) and triphosphate (7) induced platelet shape change and aggregation and inhibited PGE1-induced increase in platelet cyclic AMP. On the contrary, the corresponding 2-phenylethynyladenosine di- (6) and triphosphate (8) did not induce platelet shape change or aggregation, but inhibited platelet aggregation induced by ADP.

AB - Newly synthesized mono-, di-, and triphosphate of 2-alkynyl adenosines showed very different behavior in human platelet P2Y receptor models, according to the different alkynyl chains. In fact, 2-hexynyladenosine di- (5) and triphosphate (7) induced platelet shape change and aggregation and inhibited PGE1-induced increase in platelet cyclic AMP. On the contrary, the corresponding 2-phenylethynyladenosine di- (6) and triphosphate (8) did not induce platelet shape change or aggregation, but inhibited platelet aggregation induced by ADP.

UR - http://www.scopus.com/inward/record.url?scp=17544368426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17544368426&partnerID=8YFLogxK

U2 - 10.1021/jm0493562

DO - 10.1021/jm0493562

M3 - Article

C2 - 15828813

AN - SCOPUS:17544368426

VL - 48

SP - 2763

EP - 2766

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 8

ER -