Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors

Gloria Cristalli, Gian Marco Podda, Stefano Costanzi, Catia Lambertucci, Anna Lecchi, Sauro Vittori, Rosaria Volpini, Maddalena L. Zighetti, Marco Cattaneo

Research output: Contribution to journalArticlepeer-review

Abstract

Newly synthesized mono-, di-, and triphosphate of 2-alkynyl adenosines showed very different behavior in human platelet P2Y receptor models, according to the different alkynyl chains. In fact, 2-hexynyladenosine di- (5) and triphosphate (7) induced platelet shape change and aggregation and inhibited PGE1-induced increase in platelet cyclic AMP. On the contrary, the corresponding 2-phenylethynyladenosine di- (6) and triphosphate (8) did not induce platelet shape change or aggregation, but inhibited platelet aggregation induced by ADP.

Original languageEnglish
Pages (from-to)2763-2766
Number of pages4
JournalJournal of Medicinal Chemistry
Volume48
Issue number8
DOIs
Publication statusPublished - Apr 21 2005

ASJC Scopus subject areas

  • Organic Chemistry

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